iPTMnet Report for Q9H7N4 (SCAF1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H7N4 / SFR19_HUMAN
Protein Name Splicing factor, arginine/serine-rich 19
Gene Name Name: SCAF1
Synonyms:SFRS19,SRA1;
Organism Homo sapiens (Human)

PRO ID PR:Q9H7N4
DAG View
PRO Name splicing factor, arginine/serine-rich 19 (human)
Definition A splicing factor, arginine/serine-rich 19 that is encoded in the genome of human.
Short Label hSCAF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H7N4 (SCAF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K10 Ubiquitination PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S32 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
T159 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
Y228 Phosphorylation PhosphoSitePlus
T234 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 17081983, 20068231, ...19664995
Y238 Phosphorylation HPRD   PhosphoSitePlus 17081983
S239 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19664995, ...16565220, 19651622, 18669648, 24275569, 20166139, 18452278, 19690332, 20068231
S309 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S311 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S319 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T327 Phosphorylation PhosphoSitePlus
T330 Phosphorylation PhosphoSitePlus
T335 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T357 O-Glycosylation GlyGen 23301498, 34019948, 31373491, ...29351928
S408 Phosphorylation PhosphoSitePlus
S448 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S453 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
Y494 Phosphorylation HPRD   PhosphoSitePlus 17081983
S498 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 15302935, 18452278, 19651622, 18669648, 24275569, 19690332, 20068231, 16964243
S500 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17081983, 15302935, 19691289, 18452278, 19651622, 18669648, 19690332, 24275569, 18212344, 20068231, 16964243
T515 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S526 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983
S534 O-Glycosylation GlyGen 23301498, 34019948, 31373491, ...29351928
S548 O-Glycosylation GlyGen 23301498, 34019948, 31373491, ...29351928
S548 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664995, ...18669648, 19690332, 20068231
S552 Phosphorylation HPRD   PhosphoSitePlus 19413330
K553 Methylation PhosphoSitePlus
K554 Methylation PhosphoSitePlus
S564 Phosphorylation HPRD   PhosphoSitePlus 20068231
S567 Phosphorylation PhosphoSitePlus
S569 Phosphorylation HPRD   PhosphoSitePlus 20068231
S589 Phosphorylation HPRD   PhosphoSitePlus 18452278
T590 Phosphorylation HPRD   PhosphoSitePlus 18452278
S612 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692
S614 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692
T619 Phosphorylation PhosphoSitePlus
R635 Methylation PhosphoSitePlus
S655 Phosphorylation PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
S689 Phosphorylation PhosphoSitePlus
T706 Phosphorylation PhosphoSitePlus   UniProt 23186163
S713 Phosphorylation PhosphoSitePlus
S719 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...18669648, 20068231
S724 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 19664995
S725 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 15302935, ...19664995, 19691289, 18669648, 20068231
Y732 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 24275569
S734 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 21406692, ...23186163, 16964243, 18767875, 18452278, 19651622, 18669648, 19415658, 24275569, 19690332, 20068231, 17081983
S738 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18691976, 21406692, ...23186163, 16964243, 18452278, 19651622, 18669648, 19415658, 24275569, 19690332, 20068231, 17081983
S746 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus
S754 Phosphorylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
K794 Acetylation PhosphoSitePlus
K799 Acetylation PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
S846 Phosphorylation HPRD   phospho.ELM 18669648
T849 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S856 Phosphorylation PhosphoSitePlus
K865 Ubiquitination PhosphoSitePlus
S867 Phosphorylation PhosphoSitePlus
S872 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S874 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18767875, 19691289, 19651622, 18669648, 24275569, 20068231
T885 Phosphorylation HPRD   PhosphoSitePlus 20068231
K909 Acetylation PhosphoSitePlus
T911 Phosphorylation PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus
S929 Phosphorylation PhosphoSitePlus   UniProt 21406692
S933 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 20068231
S936 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 20068231
S941 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
S951 Phosphorylation PhosphoSitePlus
T962 Phosphorylation PhosphoSitePlus
S963 Phosphorylation HPRD   PhosphoSitePlus 17081983
S965 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...18212344, 19691289, 19651622, 18669648, 19690332, 20068231, 17081983
S975 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
T976 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...15302935, 18669648, 20068231
T989 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 15302935, ...19664995, 18669648, 24275569, 20068231
S992 Phosphorylation HPRD   PhosphoSitePlus 19413330
T994 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
S997 Phosphorylation PhosphoSitePlus
S998 Phosphorylation HPRD   phospho.ELM 18669648
C999 S-Nitrosylation dbSNO 26338901
T1001 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 21406692, ...20068231
S1005 Phosphorylation PhosphoSitePlus
S1063 Phosphorylation HPRD   phospho.ELM 18669648
S1068 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S1079 Phosphorylation PhosphoSitePlus
T1083 Phosphorylation PhosphoSitePlus
K1123 Ubiquitination PhosphoSitePlus
S1136 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus
S1177 Phosphorylation PhosphoSitePlus
T1181 Phosphorylation PhosphoSitePlus
S1197 Phosphorylation PhosphoSitePlus
K1210 Ubiquitination PhosphoSitePlus
K1222 Ubiquitination PhosphoSitePlus
K1226 Ubiquitination PhosphoSitePlus
K1240 Ubiquitination PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
S1255 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1264 Phosphorylation HPRD   PhosphoSitePlus 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S30 Y30 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S146 R146 Biomuta DOID:3571 / liver cancer [ cosmic ]
S161 C161 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
Y228 C228 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y228 D228 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y238 H238 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S309 N309 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T335 M335 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S548 L548 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S614 C614 Biomuta DOID:3571 / liver cancer [ cosmic ]
S614 F614 Biomuta DOID:4159 / skin cancer [ cosmic ]
R635 W635 Biomuta DOID:4159 / skin cancer [ cosmic ]
R635 Q635 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S724 P724 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S814 N814 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S856 T856 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S933 N933 Biomuta DOID:1319 / brain cancer [ icgc ]
S951 I951 Biomuta DOID:3571 / liver cancer [ cosmic ]
S965 F965 Biomuta DOID:4159 / skin cancer [ cosmic ]
S992 L992 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T994 I994 Biomuta DOID:4159 / skin cancer [ cosmic ]
S998 I998 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1063 F1063 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1079 P1079 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T1083 M1083 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S1136 R1136 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1169 N1169 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1177 L1177 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S1177 P1177 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1181 P1181 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]