iPTMnet Report for Q9H788 (SH2D4A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H788 / SH24A_HUMAN
Protein Name SH2 domain-containing protein 4A
Gene Name Name: SH2D4A
Synonyms:PPP1R38,SH2A;
Organism Homo sapiens (Human)

PRO ID PR:Q9H788
DAG View
PRO Name SH2 domain-containing protein 4A (human)
Definition An SH2 domain-containing protein 4A that is encoded in the genome of human.
Short Label hSH2D4A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H788 (SH2D4A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K105 Sumoylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
S118 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K126 Ubiquitination PhosphoSitePlus
K128 Methylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S172 O-Glycosylation GlyGen 30379171
S177 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K240 Methylation PhosphoSitePlus
S261 Phosphorylation Q96GD4 (AURKB) PhosphoSitePlus   UniProt 22267324, 20068231
S275 Phosphorylation PhosphoSitePlus
K303 Acetylation PhosphoSitePlus
T313 Phosphorylation PhosphoSitePlus
S315 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 20068231, 17081983
S316 Phosphorylation PhosphoSitePlus
S317 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K327 Sumoylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T122 Phosphorylation HPRD 20068231
S124 Phosphorylation HPRD 20068231
Y131 Phosphorylation HPRD 17016520, 19901323, 17389395
S261 Phosphorylation HPRD 18212344, 20068231
T313 Phosphorylation HPRD 20166139, 18452278
S315 Phosphorylation HPRD 17322306, 16964243, 18767875, ...19664994, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
S317 Phosphorylation HPRD 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K49 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K115 T115 Biomuta DOID:363 / uterine cancer [ icgc ]
S118 C118 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T122 N122 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K126 Q126 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K199 E199 Biomuta DOID:3571 / liver cancer [ cosmic ]
S235 F235 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S275 N275 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]