iPTMnet Report for Q9H6S3 (EPS8L2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H6S3 / ES8L2_HUMAN
Protein Name Epidermal growth factor receptor kinase substrate 8-like protein 2
Gene Name Name: EPS8L2
Synonyms:EPS8R2;ORFNames:PP13181;
Organism Homo sapiens (Human)

PRO ID PR:Q9H6S3
DAG View
PRO Name epidermal growth factor receptor kinase substrate 8-like protein 2 (human)
Definition An epidermal growth factor receptor kinase substrate 8-like protein 2 that is encoded in the genome of human.
Short Label hEPS8L2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H6S3 (EPS8L2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S4 Phosphorylation PhosphoSitePlus
S8 O-Glycosylation GlyGen 29485866, 29237092
S8 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
S28 Phosphorylation PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S40 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T125 Phosphorylation PhosphoSitePlus
T184 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S217 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285
S231 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus   UniProt 24275569
K251 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
S449 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18220336
S455 Phosphorylation PhosphoSitePlus
S459 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S463 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T465 Phosphorylation PhosphoSitePlus
S466 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T469 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S479 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S480 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T483 Phosphorylation PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus
T490 Phosphorylation PhosphoSitePlus
Y501 Phosphorylation PhosphoSitePlus
S512 Phosphorylation PhosphoSitePlus
Y540 Phosphorylation PhosphoSitePlus
S570 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T572 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
K663 Acetylation PhosphoSitePlus
Y678 Phosphorylation PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
K703 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 18452278
S4 Phosphorylation HPRD 18452278
S8 Phosphorylation HPRD 18452278
S217 Phosphorylation HPRD 16083285
T303 Phosphorylation HPRD 18212344
S449 Phosphorylation HPRD 20068231, 17693683
S459 Phosphorylation HPRD 18669648, 20068231
S463 Phosphorylation HPRD 19651622, 18669648, 20068231
T465 Phosphorylation HPRD 20068231
S466 Phosphorylation HPRD 18669648
T469 Phosphorylation HPRD 18669648
S479 Phosphorylation HPRD 18669648, 20068231
S480 Phosphorylation HPRD 18669648
T483 Phosphorylation HPRD 20068231
S570 Phosphorylation HPRD 18669648, 20068231, 18452278
T572 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S240 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S368 F368 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S459 F459 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S466 L466 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S466 * Biomuta DOID:263 / kidney cancer [ cosmic ]
T469 I469 Biomuta DOID:4159 / skin cancer [ cosmic ]
S479 N479 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S512 L512 Biomuta DOID:4159 / skin cancer [ cosmic ]