Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H6S0 / YTDC2_HUMAN
Protein Name 3'-5' RNA helicase YTHDC2
Gene Name Name: YTHDC2
Organism Homo sapiens (Human)

PRO ID PR:Q9H6S0
DAG View
PRO Name 3'-5' RNA helicase YTHDC2 (human)
Definition A 3'-5' RNA helicase YTHDC2 that is encoded in the genome of human.
Short Label hYTHDC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H6S0 (YTHDC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
R3 Methylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
R32 Methylation PhosphoSitePlus
K34 Methylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
T123 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
T271 Phosphorylation PhosphoSitePlus
Y274 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K399 Acetylation PhosphoSitePlus
K406 Acetylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K675 Ubiquitination PhosphoSitePlus
R736 Methylation PhosphoSitePlus
R739 Methylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
T994 Phosphorylation PhosphoSitePlus
K997 Ubiquitination PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
T1056 Phosphorylation PhosphoSitePlus
S1071 Phosphorylation PhosphoSitePlus
S1078 Phosphorylation PhosphoSitePlus
S1089 Phosphorylation PhosphoSitePlus   UniProt 19690332
S1090 Phosphorylation PhosphoSitePlus
S1092 Phosphorylation PhosphoSitePlus   UniProt 18669648
K1143 Ubiquitination PhosphoSitePlus
S1173 Phosphorylation PhosphoSitePlus
S1183 Phosphorylation PhosphoSitePlus
S1184 Phosphorylation PhosphoSitePlus
S1195 Phosphorylation PhosphoSitePlus
S1201 Phosphorylation PhosphoSitePlus
S1202 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1205 Phosphorylation PhosphoSitePlus
S1208 Phosphorylation PhosphoSitePlus
C1211 S-Nitrosylation dbSNO 26338901
T1212 Phosphorylation PhosphoSitePlus
T1213 Phosphorylation PhosphoSitePlus
K1220 Methylation PhosphoSitePlus
K1220 Ubiquitination PhosphoSitePlus
S1221 Phosphorylation PhosphoSitePlus
S1223 Phosphorylation PhosphoSitePlus
K1231 Methylation PhosphoSitePlus
S1255 Phosphorylation PhosphoSitePlus
S1263 Phosphorylation PhosphoSitePlus
C1265 S-Nitrosylation dbSNO 26338901
S1267 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus
S1272 Phosphorylation PhosphoSitePlus
S1273 Phosphorylation PhosphoSitePlus
S1277 Phosphorylation PhosphoSitePlus
S1279 Phosphorylation PhosphoSitePlus
S1281 Phosphorylation PhosphoSitePlus   UniProt 18669648
Y1290 Phosphorylation PhosphoSitePlus
K1307 Ubiquitination PhosphoSitePlus
T1313 Phosphorylation PhosphoSitePlus
K1356 Ubiquitination PhosphoSitePlus
K1426 Ubiquitination PhosphoSitePlus
T1429 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T116 I116 Biomuta DOID:1115 / sarcoma [ tcga ]
T271 A271 Biomuta DOID:363 / uterine cancer [ tcga ]
K392 T392 Biomuta DOID:363 / uterine cancer [ tcga ]
S1071 I1071 Biomuta DOID:3571 / liver cancer [ icgc ]
S1089 I1089 Biomuta DOID:1612 / breast cancer [ tcga ]
S1195 L1195 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1202 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1267 I1267 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1279 F1279 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1281 L1281 Biomuta DOID:1612 / breast cancer [ tcga ]
K1307 N1307 Biomuta DOID:3070 / malignant glioma [ tcga ]
T1313 S1313 Biomuta DOID:363 / uterine cancer [ tcga ]