iPTMnet Report for Q9H6H4 (REEP4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H6H4 / REEP4_HUMAN
Protein Name Receptor expression-enhancing protein 4
Gene Name Name: REEP4
Synonyms:C8orf20;ORFNames:PP432;
Organism Homo sapiens (Human)

PRO ID PR:Q9H6H4
DAG View
PRO Name receptor expression-enhancing protein 4 (human)
Definition A receptor expression-enhancing protein 4 that is encoded in the genome of human.
Short Label hREEP4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H6H4 (REEP4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T29 Phosphorylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
S140 O-Glycosylation GlyGen 30620550
S140 Phosphorylation PhosphoSitePlus
R147 Methylation PhosphoSitePlus
R149 Methylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
Y167 Phosphorylation PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
S194 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
T196 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
T204 Phosphorylation PhosphoSitePlus
S222 Phosphorylation PhosphoSitePlus
S224 Phosphorylation IEDB   PhosphoSitePlus 30784271
S241 Phosphorylation PhosphoSitePlus
T246 Phosphorylation PhosphoSitePlus
T250 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S253 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S257 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S150 Phosphorylation HPRD 20058876
S152 Phosphorylation HPRD 19413330, 17322306, 18578522, ...18212344, 18767875, 20058876, 19651622, 18669648, 20166139
S194 Phosphorylation HPRD 18669648, 17081983
T196 Phosphorylation HPRD 18669648, 17081983, 18452278
S202 Phosphorylation HPRD 18669648, 17081983, 18452278
T250 Phosphorylation HPRD 18669648
S253 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K111 E111 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y172 * Biomuta DOID:1319 / brain cancer [ cosmic ]
S194 G194 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T196 I196 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T246 M246 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]