iPTMnet Report for Q9H649 (NSUN3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H649 / NSUN3_HUMAN
Protein Name tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial
Gene Name Name: NSUN3
ORFNames:MSTP077,UG0651E06;
Organism Homo sapiens (Human)

PRO ID PR:Q9H649
DAG View
PRO Name tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial (human)
Definition A tRNA (cytosine(34)-C(5))-methyltransferase, mitochondrial that is encoded in the genome of human.
Short Label hNSUN3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H649 (NSUN3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD   PhosphoSitePlus 20068231
K27 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y113 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y114 Phosphorylation PhosphoSitePlus
S120 Phosphorylation HPRD   PhosphoSitePlus 20068231
S190 Phosphorylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
T307 Phosphorylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 L9 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K87 I87 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K90 N90 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc, tcga ]
Y114 C114 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K319 N319 Biomuta DOID:1324 / lung cancer [ cosmic ]