iPTMnet Report for Q9H5I5 (PIEZO2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H5I5 / PIEZ2_HUMAN
Protein Name Piezo-type mechanosensitive ion channel component 2
Gene Name Name: PIEZO2
Synonyms:C18orf30,C18orf58,FAM38B;
Organism Homo sapiens (Human)

PRO ID PR:Q9H5I5
DAG View
PRO Name piezo-type mechanosensitive ion channel component 2 (human)
Definition A piezo-type mechanosensitive ion channel component 2 that is encoded in the genome of human.
Short Label hPIEZO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H5I5 (PIEZO2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C7 Methylation IEDB 31844290
S312 Phosphorylation PhosphoSitePlus
T316 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
T396 Phosphorylation PhosphoSitePlus
Y445 Phosphorylation PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus
Y450 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
C503 Methylation IEDB 31844290
S838 Phosphorylation PhosphoSitePlus
Y975 Phosphorylation PhosphoSitePlus
S1050 Phosphorylation PhosphoSitePlus
Y1056 Phosphorylation PhosphoSitePlus
T1556 Phosphorylation PhosphoSitePlus
S1558 Phosphorylation PhosphoSitePlus
S1718 Phosphorylation PhosphoSitePlus
S1836 Phosphorylation PhosphoSitePlus
S1841 Phosphorylation PhosphoSitePlus
S1844 Phosphorylation PhosphoSitePlus
S1857 Phosphorylation PhosphoSitePlus
S1881 Phosphorylation PhosphoSitePlus
S2099 Phosphorylation PhosphoSitePlus
K2148 Ubiquitination PhosphoSitePlus
T2480 Phosphorylation PhosphoSitePlus
S2541 O-Glycosylation GlyGen 28411811, 35289036
K2545 Acetylation PhosphoSitePlus
K2552 Methylation PhosphoSitePlus
N2572 N-Glycosylation GlyGen 24190977
S2577 Phosphorylation PhosphoSitePlus
S2597 Phosphorylation PhosphoSitePlus
S2599 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y1142 Phosphorylation PhosphoSitePlus
Y1145 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S312 L312 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T316 M316 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1050 Y1050 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1844 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K2148 Q2148 Biomuta DOID:3571 / liver cancer [ cosmic ]
S2541 C2541 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K2545 T2545 Biomuta DOID:1324 / lung cancer [ icgc ]
S2577 * Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S2577 T2577 Biomuta DOID:363 / uterine cancer [ icgc ]
S2599 L2599 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]