iPTMnet Report for Q9H583 (HEATR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H583 / HEAT1_HUMAN
Protein Name HEAT repeat-containing protein 1
Gene Name Name: HEATR1
Synonyms:BAP28,UTP10;
Organism Homo sapiens (Human)

PRO ID PR:Q9H583
DAG View
PRO Name HEAT repeat-containing protein 1 (human)
Definition A HEAT repeat-containing protein 1 that is encoded in the genome of human.
Short Label hHEATR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H583 (HEATR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T2 Acetylation UniProt 22814378, 22223895
T2 Phosphorylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus
S22 Phosphorylation IEDB 35494241
K34 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
T363 Phosphorylation PhosphoSitePlus
T367 Phosphorylation PhosphoSitePlus
Y375 Phosphorylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S516 Phosphorylation PhosphoSitePlus   UniProt 23186163
K519 Ubiquitination PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K627 Ubiquitination PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
K808 Ubiquitination PhosphoSitePlus
K909 Ubiquitination PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
S929 Phosphorylation PhosphoSitePlus
C941 Methylation IEDB 31844290
T979 Phosphorylation IEDB 32387766
K995 Ubiquitination PhosphoSitePlus
K1047 Ubiquitination PhosphoSitePlus
K1054 Ubiquitination PhosphoSitePlus
Y1067 Phosphorylation PhosphoSitePlus
K1093 Ubiquitination PhosphoSitePlus
T1105 Phosphorylation PhosphoSitePlus
K1112 Ubiquitination PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
K1122 Ubiquitination PhosphoSitePlus
K1152 Ubiquitination PhosphoSitePlus
K1170 Ubiquitination PhosphoSitePlus
K1172 Ubiquitination PhosphoSitePlus
K1180 Ubiquitination PhosphoSitePlus
K1189 Ubiquitination PhosphoSitePlus
S1190 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 20068231, ...18452278
S1195 Phosphorylation PhosphoSitePlus
K1272 Ubiquitination PhosphoSitePlus
K1275 Ubiquitination PhosphoSitePlus
T1340 Phosphorylation PhosphoSitePlus
Y1341 Phosphorylation PhosphoSitePlus
S1360 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1477 Ubiquitination PhosphoSitePlus
K1483 Ubiquitination PhosphoSitePlus
S1486 Phosphorylation PhosphoSitePlus
K1489 Ubiquitination PhosphoSitePlus
S1490 Phosphorylation PhosphoSitePlus
S1492 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
K1508 Ubiquitination PhosphoSitePlus
S1517 Phosphorylation PhosphoSitePlus
S1519 Phosphorylation PhosphoSitePlus
S1526 Phosphorylation PhosphoSitePlus
S1527 Phosphorylation PhosphoSitePlus
K1533 Ubiquitination PhosphoSitePlus
S1537 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1575 Ubiquitination PhosphoSitePlus
T1597 Phosphorylation PhosphoSitePlus
T1599 Phosphorylation PhosphoSitePlus
S1614 Phosphorylation PhosphoSitePlus
K1618 Ubiquitination PhosphoSitePlus
K1626 Ubiquitination PhosphoSitePlus
K1634 Ubiquitination PhosphoSitePlus
K1655 Acetylation PhosphoSitePlus
K1675 Ubiquitination PhosphoSitePlus
K1679 Acetylation PhosphoSitePlus
K1679 Ubiquitination PhosphoSitePlus
S1794 Phosphorylation HPRD 20068231
K1811 Ubiquitination PhosphoSitePlus
T1815 Phosphorylation PhosphoSitePlus
T1816 Phosphorylation PhosphoSitePlus
R1820 Methylation PhosphoSitePlus
K1831 Acetylation PhosphoSitePlus
K1831 Ubiquitination PhosphoSitePlus
K1835 Ubiquitination PhosphoSitePlus
S1882 Phosphorylation PhosphoSitePlus
K1924 Ubiquitination PhosphoSitePlus
S1981 Phosphorylation PhosphoSitePlus
T2007 Phosphorylation PhosphoSitePlus
S2012 Phosphorylation PhosphoSitePlus
K2036 Ubiquitination PhosphoSitePlus
S2076 Phosphorylation phospho.ELM   PhosphoSitePlus 16083285
T2087 Phosphorylation HPRD   PhosphoSitePlus 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 I16 Biomuta DOID:184 / bone cancer [ cosmic ]
S22 F22 Biomuta DOID:4159 / skin cancer [ cosmic ]
S22 C22 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S22 P22 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y375 C375 Biomuta DOID:1324 / lung cancer [ cosmic ]
K568 N568 Biomuta DOID:1324 / lung cancer [ cosmic ]
K568 E568 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K655 E655 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S917 Y917 Biomuta DOID:363 / uterine cancer [ icgc ]
K1122 N1122 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K1180 Q1180 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1341 H1341 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1490 I1490 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1508 N1508 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1526 F1526 Biomuta DOID:1319 / brain cancer [ icgc ]
K1533 N1533 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1626 E1626 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1626 M1626 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1626 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1655 N1655 Biomuta DOID:363 / uterine cancer [ icgc ]
K1679 N1679 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K1811 T1811 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1820 L1820 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1981 C1981 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S2012 N2012 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]