Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4Z3 / CAPAM_HUMAN
Protein Name mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase
Gene Name Name: PCIF1
Synonyms:C20orf67;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4Z3
DAG View
PRO Name mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase (human)
Definition An mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase that is encoded in the genome of human.
Short Label hPCIF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4Z3 (PCIF1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD   PhosphoSitePlus 20068231
S14 Phosphorylation PhosphoSitePlus
S17 Phosphorylation PhosphoSitePlus
S19 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T22 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S30 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
K51 Ubiquitination PhosphoSitePlus
S116 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18767875, ...19651622, 19690332
S121 Phosphorylation PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
T137 Phosphorylation HPRD   PhosphoSitePlus 20068231
S140 Phosphorylation HPRD   PhosphoSitePlus 20068231
S143 Phosphorylation HPRD   PhosphoSitePlus 19651622
S144 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 19651622, 15302935, ...20068231
S146 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19651622, 18669648, 20068231
T150 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
T152 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 19690332, ...20068231
S159 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y175 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K241 Acetylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S305 Phosphorylation HPRD   PhosphoSitePlus 18452278
S308 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
Y432 Phosphorylation PhosphoSitePlus
S440 Phosphorylation PhosphoSitePlus
T593 Phosphorylation PhosphoSitePlus
R598 Methylation PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S675 Phosphorylation PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 N8 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S14 P14 Biomuta DOID:363 / uterine cancer [ tcga ]
S23 A23 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S144 F144 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T152 A152 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S308 I308 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S440 N440 Biomuta DOID:363 / uterine cancer [ tcga ]
S440 C440 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S673 G673 Biomuta DOID:0070003 / blastoma [ cosmic ]