iPTMnet Report for Q9H4L5 (OSBPL3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4L5 / OSBL3_HUMAN
Protein Name Oxysterol-binding protein-related protein 3
Gene Name Name: OSBPL3
Synonyms:KIAA0704,ORP3,OSBP3;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4L5
DAG View
PRO Name oxysterol-binding protein-related protein 3 (human)
Definition An oxysterol-binding protein-related protein 3 that is encoded in the genome of human.
Short Label hOSBPL3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4L5 (OSBPL3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S16 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S20 Phosphorylation PhosphoSitePlus
T21 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S22 Phosphorylation PhosphoSitePlus
S23 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S30 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus   UniProt 19369195, 23186163
Y47 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus   UniProt 23186163
S215 Phosphorylation PhosphoSitePlus
T249 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
S251 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S262 Phosphorylation PhosphoSitePlus
S265 Phosphorylation PhosphoSitePlus   UniProt 23186163, 25447204
S272 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
T288 Phosphorylation PhosphoSitePlus
S303 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S304 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 25447204, ...19690332, 20068231
S309 Phosphorylation PhosphoSitePlus   UniProt 23186163
T310 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus   UniProt 23186163, 25447204
S323 Phosphorylation PhosphoSitePlus   UniProt 25447204
Y344 Phosphorylation PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus   UniProt 25447204
S372 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 25447204, ...20068231
S374 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
S405 Phosphorylation PhosphoSitePlus
S410 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 25447204, 19369195, ...18669648, 23186163, 20068231
S416 Phosphorylation PhosphoSitePlus
S425 Phosphorylation PhosphoSitePlus   UniProt 23186163
S437 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 25447204, 18691976, ...23186163, 18088087
S440 Phosphorylation PhosphoSitePlus   UniProt 23186163
S504 Phosphorylation PhosphoSitePlus
T514 Phosphorylation PhosphoSitePlus
S523 Phosphorylation PhosphoSitePlus
S524 Phosphorylation PhosphoSitePlus
S527 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
Y565 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
Y598 Phosphorylation PhosphoSitePlus
C689 Methylation IEDB 31844290
Y717 Phosphorylation PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
Y759 Phosphorylation PhosphoSitePlus
S764 Phosphorylation PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 18669648
T21 Phosphorylation HPRD 18669648
S23 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 20068231
T249 Phosphorylation HPRD 20068231
S251 Phosphorylation HPRD 19413330, 18669648, 20068231
S303 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S304 Phosphorylation HPRD 19651622, 18691976, 18578522, ...18669648, 20068231
S320 Phosphorylation HPRD 18691976
S323 Phosphorylation HPRD 18691976
S370 Phosphorylation HPRD 19413330
S372 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19413330, 20068231
S374 Phosphorylation HPRD 19413330
S410 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S437 Phosphorylation HPRD 19651622, 18691976, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 18669648
T21 Phosphorylation HPRD 18669648
S23 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 20068231
T249 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S272 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S273 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18578522, 19651622, ...18669648, 20068231
S289 Phosphorylation HPRD 18691976
S292 Phosphorylation HPRD 18691976
S339 Phosphorylation HPRD 19413330
S341 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19413330, 20068231
S343 Phosphorylation HPRD 19413330
S379 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S406 Phosphorylation HPRD 19651622, 18691976, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 18669648
T21 Phosphorylation HPRD 18669648
S23 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 20068231
T249 Phosphorylation HPRD 20068231
S251 Phosphorylation HPRD 19413330, 18669648, 20068231
S303 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S304 Phosphorylation HPRD 19651622, 18691976, 18578522, ...18669648, 20068231
S320 Phosphorylation HPRD 18691976
S323 Phosphorylation HPRD 18691976
S370 Phosphorylation HPRD 19413330
S372 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19413330, 20068231
S374 Phosphorylation HPRD 19413330
S401 Phosphorylation HPRD 19651622, 18691976, 18088087
Site PTM Type PTM Enzyme Score Source PMID
S16 Phosphorylation HPRD 18669648
T21 Phosphorylation HPRD 18669648
S23 Phosphorylation HPRD 18669648
S200 Phosphorylation HPRD 20068231
S272 Phosphorylation HPRD 19651622, 18691976, 18669648, ...20068231
S273 Phosphorylation HPRD 19651622, 18691976, 18578522, ...18669648, 20068231
S289 Phosphorylation HPRD 18691976
S292 Phosphorylation HPRD 18691976
S339 Phosphorylation HPRD 19413330
S341 Phosphorylation HPRD 17322306, 18691976, 18669648, ...19413330, 20068231
S343 Phosphorylation HPRD 19413330
S370 Phosphorylation HPRD 19651622, 18691976, 18088087
Site PTM Type PTM Enzyme Score Source PMID
T249 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S16 L16 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S30 G30 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S34 N34 Biomuta DOID:363 / uterine cancer [ icgc ]
S34 I34 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S86 N86 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S185 G185 Biomuta DOID:1324 / lung cancer [ cosmic ]
S186 C186 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S197 N197 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S215 P215 Biomuta DOID:1324 / lung cancer [ cosmic ]
S251 L251 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S265 N265 Biomuta DOID:4159 / skin cancer [ cosmic ]
S272 F272 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S272 L272 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S289 F289 Biomuta DOID:1324 / lung cancer [ cosmic ]
S303 F303 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S309 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
K317 N317 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S320 F320 Biomuta DOID:1324 / lung cancer [ cosmic ]
S343 P343 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T346 I346 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
S370 C370 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S374 P374 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S386 F386 Biomuta DOID:4159 / skin cancer [ cosmic ]
K395 E395 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S401 C401 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, cosmic, icgc ]
S406 C406 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, cosmic, icgc ]
S416 L416 Biomuta DOID:1324 / lung cancer [ cosmic ]
S437 C437 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S440 G440 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S523 C523 Biomuta DOID:1324 / lung cancer [ cosmic ]
K538 N538 Biomuta DOID:1319 / brain cancer [ icgc ]
Y565 N565 Biomuta DOID:363 / uterine cancer [ icgc ]
Y593 H593 Biomuta DOID:9256 / colorectal cancer [ cosmic ]