iPTMnet Report for Q9H4L4 (SENP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4L4 / SENP3_HUMAN
Protein Name Sentrin-specific protease 3
Gene Name Name: SENP3
Synonyms:SSP3,SUSP3;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4L4
DAG View
PRO Name sentrin-specific protease 3 (human)
Definition A sentrin-specific protease 3 that is encoded in the genome of human.
Short Label hSENP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4L4 (SENP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K2 Methylation PhosphoSitePlus
Y24 Phosphorylation HPRD   PhosphoSitePlus 19664995
S25 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19664995, 18220336
S26 Phosphorylation HPRD   PhosphoSitePlus 19664995
K43 Methylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S54 Phosphorylation PhosphoSitePlus   UniProt 23186163
S69 Phosphorylation PhosphoSitePlus
S73 Phosphorylation HPRD   PhosphoSitePlus 18691976
S75 Phosphorylation HPRD   PhosphoSitePlus 18691976
K120 Acetylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
T142 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
S169 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18491316, 17081983, ...18220336, 19664994, 18669648, 20068231
T176 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S181 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18220336, 19664994, ...18669648, 20068231
S188 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
R190 Methylation PhosphoSitePlus
S212 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 19007248, ...19691289
S217 Phosphorylation PhosphoSitePlus
T229 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
K231 Ubiquitination PhosphoSitePlus
S232 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 17081983, 18452278, ...19651622, 18669648, 20068231
S238 Phosphorylation PhosphoSitePlus
S242 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S253 Phosphorylation HPRD 19007248
S307 Phosphorylation HPRD   PhosphoSitePlus 18691976
T353 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 16565220
K357 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
K442 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
T477 Phosphorylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
Y498 Phosphorylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K516 Ubiquitination PhosphoSitePlus
K520 Ubiquitination PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S169 L169 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S181 P181 Biomuta DOID:363 / uterine cancer [ icgc ]
S181 F181 Biomuta DOID:4159 / skin cancer [ cosmic ]
S188 P188 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R190 W190 Biomuta DOID:1725 / peritoneum cancer [ cosmic ]
S217 F217 Biomuta DOID:363 / uterine cancer [ icgc ]
S217 Y217 Biomuta DOID:363 / uterine cancer [ icgc ]
T229 I229 Biomuta [ cosmic ]
K231 E231 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K436 R436 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y498 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K558 R558 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]