iPTMnet Report for Q9H4I2 (ZHX3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4I2 / ZHX3_HUMAN
Protein Name Zinc fingers and homeoboxes protein 3
Gene Name Name: ZHX3
Synonyms:KIAA0395,TIX1;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4I2
DAG View
PRO Name zinc fingers and homeoboxes protein 3 (human)
Definition A zinc fingers and homeoboxes protein 3 that is encoded in the genome of human.
Short Label hZHX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4I2 (ZHX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y75 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
K193 Acetylation PhosphoSitePlus
S219 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
S231 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
S240 O-Glycosylation GlyGen 34846842, 33214551, 35254053, ...32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 31492838, 36240223, 30620550, 35289036, 29237092
S243 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
S246 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
K501 Ubiquitination PhosphoSitePlus
K510 Methylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S565 Phosphorylation PhosphoSitePlus
T586 O-Glycosylation GlyGen 34846842, 33214551, 35254053, ...32574038, 32938750, 34019948, 28657654, 30059200, 35132862, 31492838, 36240223, 30620550, 35289036, 29237092
T590 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
T591 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
T593 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
T596 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
S599 O-Glycosylation GlyGen 32574038
S599 Phosphorylation PhosphoSitePlus   UniProt 23186163
S604 Phosphorylation PhosphoSitePlus   UniProt 23186163
T608 Phosphorylation PhosphoSitePlus
T612 Phosphorylation PhosphoSitePlus
T614 Phosphorylation PhosphoSitePlus
S680 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S708 Phosphorylation PhosphoSitePlus
S723 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K730 Ubiquitination PhosphoSitePlus
T735 O-Glycosylation GlyGen 34846842, 33214551, 34019948, ...32574038, 30059200, 28657654, 30620550, 35132862, 31492838, 36240223, 35254053, 35289036, 29237092
S756 O-Glycosylation GlyGen 32574038
S768 Phosphorylation PhosphoSitePlus
Y817 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
S927 Phosphorylation PhosphoSitePlus   UniProt 24275569
S945 Phosphorylation PhosphoSitePlus
S946 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 19690332, ...24275569
Site PTM Type PTM Enzyme Score Source PMID
T590 Phosphorylation HPRD 20068231
T591 Phosphorylation HPRD 20068231
S604 Phosphorylation HPRD 20068231
T608 Phosphorylation HPRD 20068231
S680 Phosphorylation HPRD 18669648
S723 Phosphorylation HPRD 18669648
S927 Phosphorylation HPRD 18452278
T944 Phosphorylation HPRD 20068231
S946 Phosphorylation HPRD 19413330, 15302935, 20058876, ...18452278, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K501 R501 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S708 Y708 Biomuta DOID:1319 / brain cancer [ icgc ]
S723 N723 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S723 R723 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
T944 I944 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S945 L945 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]