iPTMnet Report for Q9H4E7 (DEF6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4E7 / DEFI6_HUMAN
Protein Name Differentially expressed in FDCP 6 homolog
Gene Name Name: DEF6
Synonyms:IBP;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4E7
DAG View
PRO Name differentially expressed in FDCP 6 homolog (human)
Definition A differentially expressed in FDCP 6 that is encoded in the genome of human.
Short Label hDEF6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4E7 (DEF6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
K28 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
Y133 Phosphorylation P06239 (LCK) Signor 18976935
Y144 Phosphorylation P06239 (LCK) PhosphoSitePlus   Signor 18976935
Y210 Phosphorylation P06239 (LCK) , Q08881 (ITK) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 22829599, 12923183
Y222 Phosphorylation Q08881 (ITK) neXtProt   PhosphoSitePlus   RLIMS-P 22829599
K225 Acetylation PhosphoSitePlus   UniProt 19608861
K318 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
T538 Phosphorylation PhosphoSitePlus
T563 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S566 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
S581 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
T595 Phosphorylation PhosphoSitePlus   RLIMS-P 28993769
S597 Phosphorylation PhosphoSitePlus   RLIMS-P 28993769
S600 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
S618 Phosphorylation PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K28 R28 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T563 P563 Biomuta DOID:1612 / breast cancer [ cosmic ]
S581 F581 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S600 I600 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]