iPTMnet Report for Q9H4B6 (SAV1)
Protein Information
UniProt AC / UniProt ID | Q9H4B6 / SAV1_HUMAN |
Protein Name | Protein salvador homolog 1 |
Gene Name | Name: SAV1 Synonyms:WW45; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9H4B6 |
PRO Name | protein salvador homolog 1 (human) |
Definition | A protein salvador homolog 1 that is encoded in the genome of human. |
Short Label | hSAV1 |
Category | organism-gene |
Q9H4B6 (SAV1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Phosphorylation | score1 | PRO | ||||
T26 | Phosphorylation | Q13188 (STK3) | score4 | HPRD PhosphoSitePlus RLIMS-P | 21944251, 32292165, 18691976 | |
S27 | Phosphorylation | Q13188 (STK3) | score3 | PhosphoSitePlus RLIMS-P | 21944251 | |
S36 | Phosphorylation | Q13188 (STK3) | score4 | PhosphoSitePlus RLIMS-P | 21944251, 32292165 | |
S55 | Phosphorylation | score0 | HPRD | 18691976 | ||
S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
S68 | Phosphorylation | score0 | RLIMS-P | 32292165 | ||
S72 | Phosphorylation | score1 | PhosphoSitePlus | |||
R75 | Methylation | score1 | PhosphoSitePlus | |||
T76 | Phosphorylation | score1 | PhosphoSitePlus | |||
S90 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18691976 | ||
R92 | Methylation | score1 | PhosphoSitePlus | |||
S94 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S97 | Phosphorylation | score1 | PhosphoSitePlus | |||
S102 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y135 | Phosphorylation | score1 | PhosphoSitePlus | |||
S136 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y158 | Phosphorylation | score1 | PhosphoSitePlus | |||
R168 | Methylation | score1 | PhosphoSitePlus | |||
S206 | Phosphorylation | score1 | PhosphoSitePlus | |||
T210 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 19369195 | ||
K258 | Ubiquitination | score1 | PhosphoSitePlus | |||
S269 | Phosphorylation | Q13188 (STK3) | score3 | PhosphoSitePlus RLIMS-P | 21944251 | |
Y273 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y357 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P31749 (AKT1) | Y26 | Q9H4B6 (SAV1) | increased_association | eFIP | 30944303 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S36 | * | Biomuta | DOID:4362 / cervical cancer [ cosmic, icgc ] | |
S68 | L68 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
S90 | R90 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S97 | F97 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
Y273 | H273 | Biomuta | DOID:3571 / liver cancer [ cosmic ] |