Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4B6 / SAV1_HUMAN
Protein Name Protein salvador homolog 1
Gene Name Name: SAV1
Synonyms:WW45;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4B6
DAG View
PRO Name protein salvador homolog 1 (human)
Definition A protein salvador homolog 1 that is encoded in the genome of human.
Short Label hSAV1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4B6 (SAV1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
T26 Phosphorylation Q13188 (STK3) HPRD   PhosphoSitePlus   RLIMS-P 18691976, 21944251
S27 Phosphorylation Q13188 (STK3) PhosphoSitePlus   RLIMS-P 21944251
S36 Phosphorylation Q13188 (STK3) PhosphoSitePlus   RLIMS-P 21944251
S55 Phosphorylation HPRD 18691976
S56 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
R75 Methylation PhosphoSitePlus
T76 Phosphorylation PhosphoSitePlus
S90 Phosphorylation HPRD   PhosphoSitePlus 18691976
R92 Methylation PhosphoSitePlus
S94 Phosphorylation PhosphoSitePlus   UniProt 23186163
S97 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
Y158 Phosphorylation PhosphoSitePlus
R168 Methylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus   UniProt 19369195
K258 Ubiquitination PhosphoSitePlus
S269 Phosphorylation Q13188 (STK3) PhosphoSitePlus   RLIMS-P 21944251
Y357 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049156 (hSAV1/PhosRes+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31749 (AKT1) Y26 Q9H4B6 (SAV1) increased_association eFIP 30944303


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S36 * Biomuta DOID:4362 / cervical cancer [ tcga ]
S90 R90 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S206 Y206 Biomuta DOID:363 / uterine cancer [ tcga ]
Y357 H357 Biomuta DOID:3070 / malignant glioma [ tcga ]