iPTMnet Report for Q9H4A4 (RNPEP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4A4 / AMPB_HUMAN
Protein Name Aminopeptidase B
Gene Name Name: RNPEP
Synonyms:APB;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4A4
DAG View
PRO Name aminopeptidase B (human)
Definition An aminopeptidase B that is encoded in the genome of human.
Short Label hRNPEP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4A4 (RNPEP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 21406692, 20068231
S3 Phosphorylation HPRD   PhosphoSitePlus 19651622, 20068231
S7 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19651622, 20068231
S10 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S19 Phosphorylation PhosphoSitePlus
S60 O-Glycosylation GlyGen 23301498, 35138101, 34725712, ...29351928, 34019948, 32870666, 32119511
S247 O-Glycosylation GlyGen 23301498, 35138101, 34725712, ...29351928, 34019948, 32870666, 32119511
K394 Ubiquitination PhosphoSitePlus
K398 Sumoylation PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
K446 Acetylation PhosphoSitePlus   UniProt 19608861
K446 Ubiquitination PhosphoSitePlus
S528 Phosphorylation PhosphoSitePlus
Y537 Phosphorylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
Y608 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 N3 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S247 I247 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T412 S412 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
T412 I412 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
Y414 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K545 N545 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]