Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H4A3 / WNK1_HUMAN
Protein Name Serine/threonine-protein kinase WNK1
Gene Name Name: WNK1
Synonyms:HSN2;
Organism Homo sapiens (Human)

PRO ID PR:Q9H4A3
DAG View
PRO Name serine/threonine-protein kinase WNK1 (human)
Definition A serine/threonine-protein kinase WNK1 that is encoded in the genome of human.
Short Label hWNK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H4A3 (WNK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
T12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S19 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S33 Phosphorylation PhosphoSitePlus
T60 Phosphorylation O00141 (SGK1) , P31749 (AKT1) , O75582 (RPS6KA5) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 14611643, 16081417, 29930759, ...21355052
R66 Methylation PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
S167 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 24275569
S170 Phosphorylation PhosphoSitePlus
S174 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 24275569
S183 Phosphorylation PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
T308 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
S378 Phosphorylation Q9H4A3 (WNK1) neXtProt   phospho.ELM   PhosphoSitePlus 17081983, 12374799
S382 Phosphorylation Q9BYP7 (WNK3) , Q9Y3S1 (WNK2) , Q9H4A3 (WNK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 17190791, 22032326, 29176664, ...18270262, 12374799
S599 Phosphorylation PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
T1098 Phosphorylation PhosphoSitePlus
Y1102 Phosphorylation PhosphoSitePlus
K1104 Acetylation PhosphoSitePlus
S1105 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
S1110 Phosphorylation PhosphoSitePlus
T1115 Phosphorylation PhosphoSitePlus
S1116 Phosphorylation PhosphoSitePlus
K1119 Acetylation PhosphoSitePlus
K1128 Acetylation PhosphoSitePlus
Y1215 Phosphorylation PhosphoSitePlus
S1220 Phosphorylation PhosphoSitePlus
S1253 Phosphorylation PhosphoSitePlus
S1261 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 16964243, 17190791, ...18669648, 22032326, 20068231
S1285 Phosphorylation PhosphoSitePlus
S1295 Phosphorylation PhosphoSitePlus
S1297 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1300 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
K1653 Ubiquitination PhosphoSitePlus
K1658 Ubiquitination PhosphoSitePlus
T1810 Phosphorylation PhosphoSitePlus
S1838 Phosphorylation PhosphoSitePlus
T1848 Phosphorylation PhosphoSitePlus
S1849 Phosphorylation PhosphoSitePlus
S1887 Phosphorylation PhosphoSitePlus
S1935 Phosphorylation PhosphoSitePlus
T1937 Phosphorylation PhosphoSitePlus
T1941 Phosphorylation PhosphoSitePlus
S1959 Phosphorylation PhosphoSitePlus
S1961 Phosphorylation PhosphoSitePlus
T1963 Phosphorylation PhosphoSitePlus
T1968 Phosphorylation PhosphoSitePlus
T1970 Phosphorylation PhosphoSitePlus
S1978 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 19690332, ...24275569
S2002 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S2005 Phosphorylation PhosphoSitePlus
S2011 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
S2012 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 17081983, 17190791
S2027 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 24275569
S2029 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 21406692, ...17190791
S2032 Phosphorylation P42345 (MTOR) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...17190791, 18669648, 21659604, 20068231
S2037 Phosphorylation PhosphoSitePlus
S2038 Phosphorylation PhosphoSitePlus
S2065 Phosphorylation PhosphoSitePlus
Y2102 Phosphorylation PhosphoSitePlus
S2121 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T2128 Phosphorylation PhosphoSitePlus
S2145 Phosphorylation PhosphoSitePlus
K2243 Ubiquitination PhosphoSitePlus
T2245 Phosphorylation PhosphoSitePlus
T2247 Phosphorylation PhosphoSitePlus
S2265 Phosphorylation PhosphoSitePlus
S2270 Phosphorylation PhosphoSitePlus
Y2276 Phosphorylation PhosphoSitePlus
S2286 Phosphorylation PhosphoSitePlus
S2294 Phosphorylation PhosphoSitePlus
S2370 Phosphorylation PhosphoSitePlus   UniProt 23186163
S2372 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17190791
R2380 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K25 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S780 Phosphorylation PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus
S2071 Phosphorylation PhosphoSitePlus


Q9H4A3 (WNK1) as PTM Enzyme



Substrate Site Score Source PMID
O95747 (OXSR1) T185 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 24191005, 16083423, 17190791
O95747 (OXSR1) S325 phospho.ELM   PhosphoSitePlus   Signor 24191005, 16083423, 17190791
Q15796 (SMAD2) S110 neXtProt 17392271
Q15796 (SMAD2) S260 neXtProt 17392271
Q15796 (SMAD2) S465 neXtProt 17392271
Q8N9I0 (SYT2) T199 neXtProt 15350218
Q8N9I0 (SYT2) T383 neXtProt 15350218
Q9H4A3 (WNK1) S378 neXtProt 12374799
Q9H4A3 (WNK1) S382 neXtProt   PhosphoSitePlus   Signor 18270262, 22032326, 12374799, ...17190791
Q9UEW8 (STK39) T231 neXtProt   PhosphoSitePlus   Signor 16263722, 16083423, 17190791
Q9UEW8 (STK39) S371 neXtProt   PhosphoSitePlus   Signor 17190791, 18270262, 16083423, ...16263722
Q9UHW9 (SLC12A6) T991 neXtProt   PhosphoSitePlus   Signor 19665974
Q9UHW9 (SLC12A6) T1048 neXtProt   PhosphoSitePlus   Signor 19665974


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T60 I60 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R66 S66 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T74 A74 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T1098 I1098 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1253 F1253 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1300 C1300 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S1300 P1300 Biomuta DOID:363 / uterine cancer [ tcga ]
K1653 M1653 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1961 L1961 Biomuta DOID:1324 / lung cancer [ tcga ]
T1970 P1970 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S2145 N2145 Biomuta DOID:363 / uterine cancer [ tcga ]
S2265 L2265 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S2370 F2370 Biomuta DOID:1909 / melanoma [ tcga ]