iPTMnet Report for Q9H422 (HIPK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H422 / HIPK3_HUMAN
Protein Name Homeodomain-interacting protein kinase 3
Gene Name Name: HIPK3
Synonyms:DYRK6,FIST3,PKY;
Organism Homo sapiens (Human)

PRO ID PR:Q9H422
DAG View
PRO Name homeodomain-interacting protein kinase 3 (human)
Definition A homeodomain-interacting protein kinase 3 that is encoded in the genome of human.
Short Label hHIPK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H422 (HIPK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y8 Phosphorylation PhosphoSitePlus
K27 Sumoylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
T156 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus
T358 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 16497976
S362 Phosphorylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
K492 Ubiquitination PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
T515 Phosphorylation PhosphoSitePlus
T519 Phosphorylation PhosphoSitePlus
K528 Methylation PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
S572 O-Glycosylation GlyGen 32938750
K813 Ubiquitination PhosphoSitePlus
K852 Ubiquitination PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
C1141 Methylation IEDB 31844290
S1205 Phosphorylation IEDB   PhosphoSitePlus 32387766
Site PTM Type PTM Enzyme Score Source PMID
Y359 Phosphorylation HPRD 15592455, 19901323, 16497976
Site PTM Type PTM Enzyme Score Source PMID
Y359 Phosphorylation HPRD 15592455, 19901323, 16497976
S772 Phosphorylation PhosphoSitePlus


Q9H422 (HIPK3) as PTM Enzyme



Substrate Site Score Source PMID
Q13158 (FADD) S194 HPRD   phospho.ELM 19413330, 20230923, 19664995, ...10640736, 11034606, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K58 M58 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
K341 T341 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T358 P358 Biomuta DOID:4159 / skin cancer [ cosmic ]
K428 R428 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K435 N435 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S1205 G1205 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1205 N1205 Biomuta DOID:363 / uterine cancer [ icgc ]