Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H3M7 / TXNIP_HUMAN
Protein Name Thioredoxin-interacting protein
Gene Name Name: TXNIP
Synonyms:VDUP1;
Organism Homo sapiens (Human)

PRO ID PR:Q9H3M7
DAG View
PRO Name thioredoxin-interacting protein (human)
Definition A thioredoxin-interacting protein that is encoded in the genome of human.
Short Label hTXNIP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H3M7 (TXNIP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K8 Sumoylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
K19 Sumoylation PhosphoSitePlus
K19 Ubiquitination PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K100 Sumoylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K115 Sumoylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K117 Sumoylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K140 Sumoylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K163 Sumoylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K167 Sumoylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K212 Sumoylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus   UniProt 20068034
K228 Sumoylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K233 Sumoylation PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K287 Sumoylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus
S314 Phosphorylation RLIMS-P 30410860
S318 Phosphorylation PhosphoSitePlus
S346 Phosphorylation RLIMS-P 30410860
T348 Phosphorylation PhosphoSitePlus
T349 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 31320475, 30410860
S358 Phosphorylation PhosphoSitePlus
S361 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 30410860
T377 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
T379 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T349 Phosphorylation HPRD 18669648, 20068231
S358 Phosphorylation HPRD 20068231
S361 Phosphorylation HPRD 18669648, 20068231


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H3M7 (TXNIP) S361 Q92905 (COPS5) unknown eFIP 30410860


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 Y9 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ] DOID:263 / kidney cancer [ tcga ]
K19 N19 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y69 C69 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y69 H69 Biomuta DOID:1790 / malignant mesothelioma [ tcga ]
K140 N140 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K141 N141 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K167 R167 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K187 N187 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K212 T212 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S307 Y307 Biomuta DOID:1324 / lung cancer [ cosmic ]
T349 S349 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]