iPTMnet Report for Q9H3M7 (TXNIP)
Protein Information
| UniProt AC / UniProt ID | Q9H3M7 / TXNIP_HUMAN |
| Protein Name | Thioredoxin-interacting protein |
| Gene Name | Name: TXNIP Synonyms:VDUP1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9H3M7 |
| PRO Name | thioredoxin-interacting protein (human) |
| Definition | A thioredoxin-interacting protein that is encoded in the genome of human. |
| Short Label | hTXNIP |
| Category | organism-gene |
Q9H3M7 (TXNIP) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| K8 | Sumoylation | score1 | PhosphoSitePlus | |||
| S9 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K19 | Sumoylation | score1 | PhosphoSitePlus | |||
| K19 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C36 | Methylation | score1 | IEDB | 31844290 | ||
| C49 | Methylation | score1 | IEDB | 31844290 | ||
| K53 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S60 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K96 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K100 | Sumoylation | score1 | PhosphoSitePlus | |||
| K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K115 | Sumoylation | score1 | PhosphoSitePlus | |||
| K115 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K117 | Sumoylation | score1 | PhosphoSitePlus | |||
| K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K140 | Sumoylation | score1 | PhosphoSitePlus | |||
| K140 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K163 | Sumoylation | score1 | PhosphoSitePlus | |||
| K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K167 | Sumoylation | score1 | PhosphoSitePlus | |||
| K187 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K212 | Sumoylation | score1 | PhosphoSitePlus | |||
| K212 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 20068034 | ||
| K228 | Sumoylation | score1 | PhosphoSitePlus | |||
| K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K233 | Sumoylation | score1 | PhosphoSitePlus | |||
| K233 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S236 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
| C247 | Methylation | score1 | IEDB | 31844290 | ||
| K259 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K287 | Sumoylation | score1 | PhosphoSitePlus | |||
| K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S303 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S307 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S308 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S314 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 30410860 | ||
| S318 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S346 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 30410860 | ||
| T348 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T349 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 18669648, 30410860 | ||
| S358 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S361 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 18669648, 30410860 | ||
| T377 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y378 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T379 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
| PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
|---|---|---|---|---|---|---|---|
| Phosphorylation | Q9H3M7 (TXNIP) | S361 | Q92905 (COPS5) | unknown | eFIP | 30410860 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S9 | Y9 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
| K19 | N19 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| K53 | E53 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| Y69 | C69 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
| K117 | N117 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| K140 | N140 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| K141 | N141 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| K167 | R167 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| K187 | N187 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| K212 | T212 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
| S236 | L236 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| S307 | Y307 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| T349 | S349 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
DAG View