iPTMnet Report for Q9H3M7 (TXNIP)
Protein Information
UniProt AC / UniProt ID | Q9H3M7 / TXNIP_HUMAN |
Protein Name | Thioredoxin-interacting protein |
Gene Name | Name: TXNIP Synonyms:VDUP1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9H3M7 |
PRO Name | thioredoxin-interacting protein (human) |
Definition | A thioredoxin-interacting protein that is encoded in the genome of human. |
Short Label | hTXNIP |
Category | organism-gene |
Q9H3M7 (TXNIP) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
K8 | Sumoylation | score1 | PhosphoSitePlus | |||
S9 | Phosphorylation | score1 | PhosphoSitePlus | |||
K19 | Sumoylation | score1 | PhosphoSitePlus | |||
K19 | Ubiquitination | score1 | PhosphoSitePlus | |||
K26 | Ubiquitination | score1 | PhosphoSitePlus | |||
C36 | Methylation | score1 | IEDB | 31844290 | ||
C49 | Methylation | score1 | IEDB | 31844290 | ||
K53 | Ubiquitination | score1 | PhosphoSitePlus | |||
S60 | Phosphorylation | score1 | PhosphoSitePlus | |||
K64 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y69 | Phosphorylation | score1 | PhosphoSitePlus | |||
K96 | Ubiquitination | score1 | PhosphoSitePlus | |||
K100 | Sumoylation | score1 | PhosphoSitePlus | |||
K100 | Ubiquitination | score1 | PhosphoSitePlus | |||
K115 | Sumoylation | score1 | PhosphoSitePlus | |||
K115 | Ubiquitination | score1 | PhosphoSitePlus | |||
K117 | Sumoylation | score1 | PhosphoSitePlus | |||
K117 | Ubiquitination | score1 | PhosphoSitePlus | |||
K140 | Sumoylation | score1 | PhosphoSitePlus | |||
K140 | Ubiquitination | score1 | PhosphoSitePlus | |||
K141 | Ubiquitination | score1 | PhosphoSitePlus | |||
K163 | Sumoylation | score1 | PhosphoSitePlus | |||
K163 | Ubiquitination | score1 | PhosphoSitePlus | |||
K164 | Ubiquitination | score1 | PhosphoSitePlus | |||
K167 | Sumoylation | score1 | PhosphoSitePlus | |||
K187 | Ubiquitination | score1 | PhosphoSitePlus | |||
K212 | Sumoylation | score1 | PhosphoSitePlus | |||
K212 | Ubiquitination | score3 | PhosphoSitePlus UniProt | 20068034 | ||
K228 | Sumoylation | score1 | PhosphoSitePlus | |||
K228 | Ubiquitination | score1 | PhosphoSitePlus | |||
K233 | Sumoylation | score1 | PhosphoSitePlus | |||
K233 | Ubiquitination | score1 | PhosphoSitePlus | |||
S236 | O-Glycosylation | score1 | GlyGen | 31373491 | ||
C247 | Methylation | score1 | IEDB | 31844290 | ||
K259 | Ubiquitination | score1 | PhosphoSitePlus | |||
K287 | Sumoylation | score1 | PhosphoSitePlus | |||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
S303 | Phosphorylation | score1 | PhosphoSitePlus | |||
S304 | Phosphorylation | score1 | PhosphoSitePlus | |||
S307 | Phosphorylation | score1 | PhosphoSitePlus | |||
S308 | Phosphorylation | score1 | PhosphoSitePlus | |||
S314 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 30410860 | ||
S318 | Phosphorylation | score1 | PhosphoSitePlus | |||
S346 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 30410860 | ||
T348 | Phosphorylation | score1 | PhosphoSitePlus | |||
T349 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P | 18669648, 30410860 | ||
S358 | Phosphorylation | score1 | PhosphoSitePlus | |||
S361 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus RLIMS-P UniProt | 18669648, 30410860 | ||
T377 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y378 | Phosphorylation | score1 | PhosphoSitePlus | |||
T379 | Phosphorylation | score1 | PhosphoSitePlus |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | Q9H3M7 (TXNIP) | S361 | Q92905 (COPS5) | unknown | eFIP | 30410860 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S9 | Y9 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] | |
K19 | N19 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
K53 | E53 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
Y69 | C69 | Biomuta | DOID:363 / uterine cancer [ cosmic ] | |
K117 | N117 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
K140 | N140 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
K141 | N141 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
K167 | R167 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
K187 | N187 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K212 | T212 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic ] | |
S236 | L236 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
S307 | Y307 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
T349 | S349 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |