Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H3D4 / P63_HUMAN
Protein Name Tumor protein 63
Gene Name Name: TP63
Synonyms:KET,P63,P73H,P73L,TP73L;
Organism Homo sapiens (Human)

PRO ID PR:Q9H3D4
DAG View
PRO Name tumor protein 63 (human)
Definition A tumor protein 63 that is encoded in the genome of human.
Short Label hTP63
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H3D4 (TP63) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation PhosphoSitePlus
Y18 Phosphorylation PhosphoSitePlus
Y36 Phosphorylation PhosphoSitePlus
S43 Phosphorylation O14920 (IKBKB) PhosphoSitePlus 23589370
T46 Phosphorylation PhosphoSitePlus
S51 Phosphorylation O14920 (IKBKB) PhosphoSitePlus 23589370
S68 Phosphorylation P36897 (TGFBR1) Signor 23166821
Y149 Phosphorylation P00519 (ABL1) PhosphoSitePlus 19783996
S160 Phosphorylation P36897 (TGFBR1) PhosphoSitePlus   RLIMS-P   Signor 23166821, 27122225
S162 Phosphorylation PhosphoSitePlus   RLIMS-P 27122225
Y171 Phosphorylation P00519 (ABL1) PhosphoSitePlus 19783996
Y231 Phosphorylation PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
K242 Methylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus   RLIMS-P 29559659
Y290 Phosphorylation P00519 (ABL1) PhosphoSitePlus 19783996
T326 Phosphorylation PhosphoSitePlus
T329 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
S463 Phosphorylation PhosphoSitePlus
S477 Phosphorylation P23443 (RPS6KB1) , Q13315 (ATM) , P24941 (CDK2) PhosphoSitePlus   Signor 18769144
S479 Phosphorylation Q13315 (ATM) PhosphoSitePlus 18769144
T491 Phosphorylation Q13315 (ATM) , P24941 (CDK2) , P23443 (RPS6KB1) , Q9H2X6 (HIPK2) neXtProt   PhosphoSitePlus   Signor 21602882, 18769144
S560 Phosphorylation Q13315 (ATM) , P23443 (RPS6KB1) , P24941 (CDK2) PhosphoSitePlus   Signor 18769144
K588 Sumoylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
K676 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T326 Phosphorylation HPRD 19413330
T329 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation P36897 (TGFBR1) PhosphoSitePlus 23166821
S68 Phosphorylation P36897 (TGFBR1) PhosphoSitePlus 23166821
S301 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
T397 Phosphorylation Q9H2X6 (HIPK2) neXtProt 21602882


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S68 L68 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S160 C160 Biomuta DOID:1324 / lung cancer [ tcga ]
S162 L162 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y171 C171 Biomuta DOID:1909 / melanoma [ cosmic ]
T281 R281 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T329 P329 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S358 I358 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K588 I588 Biomuta DOID:1909 / melanoma [ tcga ]