iPTMnet Report Q9H300 PARL

Protein Information

Cytoscape View

UniProt AC / UniProt ID	Q9H300 / PARL_HUMAN
Protein Name	Presenilin-associated rhomboid-like protein, mitochondrial precursor
Gene Name	Name: PARL Synonyms:PSARL;ORFNames:PRO2207;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9H300 DAG View
PRO Name	presenilins-associated rhomboid-like protein, mitochondrial (human)
Definition	A presenilins-associated rhomboid-like protein, mitochondrial that is encoded in the genome of human.
Short Label	hPARL
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9H300 (PARL) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S65	Phosphorylation		score3	PhosphoSitePlus UniProt	17116872
	T69	Phosphorylation		score3	PhosphoSitePlus UniProt	17116872
	S70	Phosphorylation		score3	PhosphoSitePlus UniProt	17116872
	K75	Ubiquitination		score1	PhosphoSitePlus
	K136	Ubiquitination		score1	PhosphoSitePlus
	K147	Ubiquitination		score1	PhosphoSitePlus
	T282	Phosphorylation		score1	PhosphoSitePlus
	K362	Ubiquitination		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S65	Phosphorylation		score1	HPRD	17116872
	T69	Phosphorylation		score1	HPRD	17116872
	S70	Phosphorylation		score1	HPRD	17116872

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S65	L65	Biomuta		DOID:1612 / breast cancer [ cosmic, icgc ]