iPTMnet Report for Q9H2X6 (HIPK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H2X6 / HIPK2_HUMAN
Protein Name Homeodomain-interacting protein kinase 2
Gene Name Name: HIPK2
Organism Homo sapiens (Human)

PRO ID PR:Q9H2X6
DAG View
PRO Name homeodomain-interacting protein kinase 2 (human)
Definition A homeodomain-interacting protein kinase 2 that is encoded in the genome of human.
Short Label hHIPK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H2X6 (HIPK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
K32 Sumoylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus   RLIMS-P 21932419, 27901482
T119 Phosphorylation PhosphoSitePlus   RLIMS-P 28060750
S121 Phosphorylation PhosphoSitePlus   RLIMS-P 28060750
T221 Phosphorylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
Y264 Phosphorylation PhosphoSitePlus
S317 O-Glycosylation GlyGen 30379171, 31932432
S336 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
T360 Phosphorylation P00519 (ABL1) PhosphoSitePlus 25944899
Y361 Phosphorylation Q9H2X6 (HIPK2) , P12931 (SRC) phospho.ELM   PhosphoSitePlus   RLIMS-P 29277937, 25630557, 18083107, ...23565059, 23000554, 24196445
S364 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus 23000554
Y367 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P   Signor 28060750, 25944899
Y423 Phosphorylation PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus
Y443 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
K552 Ubiquitination PhosphoSitePlus
Y558 Phosphorylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus   RLIMS-P 28060750
S668 Phosphorylation PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
T796 Phosphorylation PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
K805 Ubiquitination PhosphoSitePlus
S826 Phosphorylation PhosphoSitePlus
S827 Phosphorylation IEDB   PhosphoSitePlus 27869121
T838 Phosphorylation PhosphoSitePlus
S848 Phosphorylation PhosphoSitePlus
S852 O-Glycosylation GlyGen 30379171, 31932432
T880 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus 24145406
S882 Phosphorylation Q9H2X6 (HIPK2) PhosphoSitePlus 24145406
S924 Phosphorylation PhosphoSitePlus
S934 Phosphorylation PhosphoSitePlus
K953 Sumoylation PhosphoSitePlus
T1009 O-Glycosylation GlyGen 30379171, 31932432
T1114 Phosphorylation PhosphoSitePlus   RLIMS-P 28060750
Y1136 Phosphorylation PhosphoSitePlus
S1147 O-Glycosylation GlyGen 30379171, 31932432
R1151 Methylation PhosphoSitePlus
S1188 Phosphorylation IEDB   PhosphoSitePlus 27869121
K1191 Sumoylation PhosphoSitePlus
K1191 Ubiquitination PhosphoSitePlus
Y1197 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y361 Phosphorylation HPRD 19901323, 19664994, 19664995


Q9H2X6 (HIPK2) as PTM Enzyme



Substrate Site Score Source PMID
O00257 (CBX4) T497 neXtProt   PhosphoSitePlus 17018294
O15297 (PPM1D) S85 PhosphoSitePlus 23871434
O43255 (SIAH2) T26 neXtProt 19043406
O43255 (SIAH2) S28 neXtProt   PhosphoSitePlus 19043406
O43255 (SIAH2) S68 neXtProt 19043406
P04637 (TP53) S46 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 11780126, 11740489, 16212962, ...19828042, 16601678, 15526030, 17203463, 17210684, 16729035, 20123963, 19465479, 17332358, 11875057, 22011578, 16738336
P16220 (CREB1) S257 Signor 20573984
P17096 (HMGA1) S36 neXtProt   PhosphoSitePlus   Signor 17960875, 11593421
P17096-2 (HMGA1) T42 PhosphoSitePlus 17960875
P17096 (HMGA1) T53 neXtProt   PhosphoSitePlus   Signor 17960875, 11593421
P17096-2 (HMGA1) T67 PhosphoSitePlus 17960875
P17096 (HMGA1) T78 neXtProt   PhosphoSitePlus 17960875, 11593421
P17676 (CEBPB) T235 PhosphoSitePlus 23782693
P18846 (ATF1) S198 neXtProt 20980392
P26367-1 (PAX6) T281 HPRD   neXtProt   Signor 16407227
P26367-2 (PAX6) T295 HPRD 16407227
P26367-1 (PAX6) T304 HPRD   neXtProt   Signor 16407227
P26367-2 (PAX6) T317 HPRD 16407227
P26367 (PAX6) T373 HPRD   neXtProt   Signor 16407227
P26367-2 (PAX6) T387 HPRD 16407227
P29590 (PML) S8 neXtProt   PhosphoSitePlus   Signor 19015637
P29590 (PML) S36 neXtProt   PhosphoSitePlus 19015637
P29590 (PML) S38 neXtProt   phospho.ELM   PhosphoSitePlus   Signor 19015637
P35222 (CTNNB1) S33 neXtProt 20307497
P35222 (CTNNB1) S37 neXtProt 20307497
P46527 (CDKN1B) S10 neXtProt   PhosphoSitePlus   Signor 21715331
P51608 (MECP2) S80 neXtProt 19820693
P52945 (PDX1) S268 neXtProt 20637728
P56545 (CTBP2) S428 PhosphoSitePlus 25659434
P57682 (KLF3) S71 PhosphoSitePlus 25659434
P57682 (KLF3) S78 PhosphoSitePlus 25659434
P57682 (KLF3) S92 PhosphoSitePlus 25659434
P57682 (KLF3) S101 PhosphoSitePlus 25659434
P57682 (KLF3) S108 PhosphoSitePlus 25659434
P57682 (KLF3) S111 PhosphoSitePlus 25659434
P57682 (KLF3) S216 PhosphoSitePlus 25659434
P57682 (KLF3) S224 PhosphoSitePlus 25659434
P57682 (KLF3) S250 PhosphoSitePlus 25659434
Q01196-1 (RUNX1) S249 HPRD   neXtProt   PhosphoSitePlus 169175071, 16917507, 18695000
Q01196 (RUNX1) T273 PhosphoSitePlus 18695000
Q01196-1 (RUNX1) S276 HPRD   neXtProt   PhosphoSitePlus 16917507, 18695000
Q13363 (CTBP1) S422 neXtProt   PhosphoSitePlus   Signor 14567915, 15708980
Q96EB6 (SIRT1) S27 PhosphoSitePlus 26113041
Q96EB6 (SIRT1) S682 PhosphoSitePlus 26113041
Q9H2X6 (HIPK2) Y361 PhosphoSitePlus 23000554
Q9H2X6 (HIPK2) S364 PhosphoSitePlus 23000554
Q9H2X6 (HIPK2) T880 PhosphoSitePlus 24145406
Q9H2X6 (HIPK2) S882 PhosphoSitePlus 24145406
Q9H3D4-2 (TP63) T397 neXtProt 21602882
Q9H3D4 (TP63) T491 PhosphoSitePlus 21602882
Q9P1Z0 (ZBTB4) T795 neXtProt   PhosphoSitePlus 19448668
Q9P1Z0 (ZBTB4) T797 neXtProt   PhosphoSitePlus 19448668
Q9P1Z0 (ZBTB4) T983 neXtProt   PhosphoSitePlus 19448668


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047698 (hHIPK2/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K32 N32 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y44 H44 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S121 G121 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K228 N228 Biomuta DOID:363 / uterine cancer [ icgc ]
K343 N343 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K355 T355 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y558 D558 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S882 G882 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R1151 Q1151 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1197 S1197 Biomuta [ cosmic ]