iPTMnet Report Q9H2X6 HIPK2

Protein Information

UniProt AC / UniProt ID	Q9H2X6 / HIPK2_HUMAN
Protein Name	Homeodomain-interacting protein kinase 2
Gene Name	Name: HIPK2
Organism	Homo sapiens (Human)

PRO ID	PR:Q9H2X6 DAG View
PRO Name	homeodomain-interacting protein kinase 2 (human)
Definition	A homeodomain-interacting protein kinase 2 that is encoded in the genome of human.
Short Label	hHIPK2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9H2X6 (HIPK2) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K32 Y44 S46 T119 S121 T221 K228 K231 Y258 Y264 S317 S336 Y340 K343 K355 S359 T360 Y361 S364 Y367 Y423 K430 S441 Y443 K506 K514 K552 Y558 K565 T566 S668 K671 T796 K803 K805 S826 S827 T838 S848 S852 T880 S882 S924 S934 K953 T1009 T1114 Y1136 S1147 R1151 S1188 K1191 Y1197	PTM Type Select all Methylation O-Glycosylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 3 4	Source Select all GlyGen IEDB PRO PhosphoSitePlus RLIMS-P Signor phospho.ELM	PMID
	Phosphorylation		score1	PRO
K32	Sumoylation		score1	PhosphoSitePlus
K32	Ubiquitination		score1	PhosphoSitePlus
Y44	Phosphorylation		score1	PhosphoSitePlus
S46	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	21932419, 27901482
T119	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28060750
S121	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28060750
T221	Phosphorylation		score1	PhosphoSitePlus
K228	Ubiquitination		score1	PhosphoSitePlus
K231	Ubiquitination		score1	PhosphoSitePlus
Y258	Phosphorylation		score1	PhosphoSitePlus
Y264	Phosphorylation		score1	PhosphoSitePlus
S317	O-Glycosylation		score3	GlyGen	30379171, 31932432
S336	Phosphorylation		score1	PhosphoSitePlus
Y340	Phosphorylation		score1	PhosphoSitePlus
K343	Ubiquitination		score1	PhosphoSitePlus
K355	Ubiquitination		score1	PhosphoSitePlus
S359	Phosphorylation		score1	PhosphoSitePlus
T360	Phosphorylation	P00519 (ABL1)	score2	PhosphoSitePlus	25944899
Y361	Phosphorylation	Q9H2X6 (HIPK2) , P12931 (SRC)	score4	phospho.ELM PhosphoSitePlus RLIMS-P	29277937, 25630557, 18083107, ...23565059, 23000554, 24196445
S364	Phosphorylation	Q9H2X6 (HIPK2)	score2	PhosphoSitePlus	23000554
Y367	Phosphorylation	P00519 (ABL1)	score4	PhosphoSitePlus RLIMS-P Signor	28060750, 25944899
Y423	Phosphorylation		score1	PhosphoSitePlus
K430	Ubiquitination		score1	PhosphoSitePlus
S441	Phosphorylation		score1	PhosphoSitePlus
Y443	Phosphorylation		score1	PhosphoSitePlus
K506	Ubiquitination		score1	PhosphoSitePlus
K514	Ubiquitination		score1	PhosphoSitePlus
K552	Ubiquitination		score1	PhosphoSitePlus
Y558	Phosphorylation		score1	PhosphoSitePlus
K565	Ubiquitination		score1	PhosphoSitePlus
T566	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28060750
S668	Phosphorylation		score1	PhosphoSitePlus
K671	Ubiquitination		score1	PhosphoSitePlus
T796	Phosphorylation		score1	PhosphoSitePlus
K803	Ubiquitination		score1	PhosphoSitePlus
K805	Ubiquitination		score1	PhosphoSitePlus
S826	Phosphorylation		score1	PhosphoSitePlus
S827	Phosphorylation		score2	IEDB PhosphoSitePlus	27869121
T838	Phosphorylation		score1	PhosphoSitePlus
S848	Phosphorylation		score1	PhosphoSitePlus
S852	O-Glycosylation		score3	GlyGen	30379171, 31932432
T880	Phosphorylation	Q9H2X6 (HIPK2)	score2	PhosphoSitePlus	24145406
S882	Phosphorylation	Q9H2X6 (HIPK2)	score2	PhosphoSitePlus	24145406
S924	Phosphorylation		score1	PhosphoSitePlus
S934	Phosphorylation		score1	PhosphoSitePlus
K953	Sumoylation		score1	PhosphoSitePlus
T1009	O-Glycosylation		score3	GlyGen	30379171, 31932432
T1114	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28060750
Y1136	Phosphorylation		score1	PhosphoSitePlus
S1147	O-Glycosylation		score3	GlyGen	30379171, 31932432
R1151	Methylation		score1	PhosphoSitePlus
S1188	Phosphorylation		score2	IEDB PhosphoSitePlus	27869121
K1191	Sumoylation		score1	PhosphoSitePlus
K1191	Ubiquitination		score1	PhosphoSitePlus
Y1197	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Tyrosine By position Y361	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0	Source Select all HPRD	PMID
	Y361	Phosphorylation		score0	HPRD	19901323, 19664994, 19664995

Q9H2X6 (HIPK2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all O00257 (CBX4) O15297 (PPM1D) O43255 (SIAH2) P04637 (TP53) P16220 (CREB1) P17096 (HMGA1) P17096-2 (HMGA1) P17676 (CEBPB) P18846 (ATF1) P26367 (PAX6) P26367-1 (PAX6) P26367-2 (PAX6) P29590 (PML) P35222 (CTNNB1) P46527 (CDKN1B) P51608 (MECP2) P52945 (PDX1) P56545 (CTBP2) P57682 (KLF3) Q01196 (RUNX1) Q01196-1 (RUNX1) Q13363 (CTBP1) Q96EB6 (SIRT1) Q9H2X6 (HIPK2) Q9H3D4 (TP63) Q9H3D4-2 (TP63) Q9P1Z0 (ZBTB4)	Site Select all By amino acid All Serine All Threonine All Tyrosine By position S8 S10 T26 S27 S28 S33 S36 S37 S38 T42 S46 T53 T67 S68 S71 T78 S78 S80 S85 S92 S101 S108 S111 S198 S216 S224 T235 S249 S250 S257 S268 T273 S276 T281 T295 T304 T317 Y361 S364 T373 T387 T397 S422 S428 T491 T497 S682 T795 T797 T880 S882 T983	Score Select all 1 2 3 4	Source Select all HPRD PhosphoSitePlus RLIMS-P+ Signor neXtProt phospho.ELM	PMID
O00257 (CBX4)	T497	score3	neXtProt PhosphoSitePlus	17018294
O15297 (PPM1D)	S85	score2	PhosphoSitePlus	23871434
O43255 (SIAH2)	T26	score2	neXtProt	19043406
O43255 (SIAH2)	S28	score3	neXtProt PhosphoSitePlus	19043406
O43255 (SIAH2)	S68	score2	neXtProt	19043406
P04637 (TP53)	S46	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P+ Signor	11780126, 11740489, 16212962, ...19828042, 16601678, 15526030, 17203463, 17210684, 16729035, 20123963, 19465479, 17332358, 11875057, 22011578, 16738336
P16220 (CREB1)	S257	score1	Signor	20573984
P17096 (HMGA1)	S36	score4	neXtProt PhosphoSitePlus Signor	17960875, 11593421
P17096-2 (HMGA1)	T42	score2	PhosphoSitePlus	17960875
P17096 (HMGA1)	T53	score4	neXtProt PhosphoSitePlus Signor	17960875, 11593421
P17096-2 (HMGA1)	T67	score2	PhosphoSitePlus	17960875
P17096 (HMGA1)	T78	score4	neXtProt PhosphoSitePlus	17960875, 11593421
P17676 (CEBPB)	T235	score2	PhosphoSitePlus	23782693
P18846 (ATF1)	S198	score2	neXtProt	20980392
P26367-1 (PAX6)	T281	score3	HPRD neXtProt Signor	16407227
P26367-2 (PAX6)	T295	score1	HPRD	16407227
P26367-1 (PAX6)	T304	score3	HPRD neXtProt Signor	16407227
P26367-2 (PAX6)	T317	score1	HPRD	16407227
P26367 (PAX6)	T373	score3	HPRD neXtProt Signor	16407227
P26367-2 (PAX6)	T387	score1	HPRD	16407227
P29590 (PML)	S8	score3	neXtProt PhosphoSitePlus Signor	19015637
P29590 (PML)	S36	score3	neXtProt PhosphoSitePlus	19015637
P29590 (PML)	S38	score3	neXtProt phospho.ELM PhosphoSitePlus Signor	19015637
P35222 (CTNNB1)	S33	score2	neXtProt	20307497
P35222 (CTNNB1)	S37	score2	neXtProt	20307497
P46527 (CDKN1B)	S10	score3	neXtProt PhosphoSitePlus Signor	21715331
P51608 (MECP2)	S80	score2	neXtProt	19820693
P52945 (PDX1)	S268	score2	neXtProt	20637728
P56545 (CTBP2)	S428	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S71	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S78	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S92	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S101	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S108	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S111	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S216	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S224	score2	PhosphoSitePlus	25659434
P57682 (KLF3)	S250	score2	PhosphoSitePlus	25659434
Q01196-1 (RUNX1)	S249	score4	HPRD neXtProt PhosphoSitePlus	169175071, 16917507, 18695000
Q01196 (RUNX1)	T273	score2	PhosphoSitePlus	18695000
Q01196-1 (RUNX1)	S276	score4	HPRD neXtProt PhosphoSitePlus	16917507, 18695000
Q13363 (CTBP1)	S422	score4	neXtProt PhosphoSitePlus Signor	14567915, 15708980
Q96EB6 (SIRT1)	S27	score2	PhosphoSitePlus	26113041
Q96EB6 (SIRT1)	S682	score2	PhosphoSitePlus	26113041
Q9H2X6 (HIPK2)	Y361	score2	PhosphoSitePlus	23000554
Q9H2X6 (HIPK2)	S364	score2	PhosphoSitePlus	23000554
Q9H2X6 (HIPK2)	T880	score2	PhosphoSitePlus	24145406
Q9H2X6 (HIPK2)	S882	score2	PhosphoSitePlus	24145406
Q9H3D4-2 (TP63)	T397	score2	neXtProt	21602882
Q9H3D4 (TP63)	T491	score2	PhosphoSitePlus	21602882
Q9P1Z0 (ZBTB4)	T795	score3	neXtProt PhosphoSitePlus	19448668
Q9P1Z0 (ZBTB4)	T797	score3	neXtProt PhosphoSitePlus	19448668
Q9P1Z0 (ZBTB4)	T983	score3	neXtProt PhosphoSitePlus	19448668

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000047698 (hHIPK2/PhosRes+)	Sites Select all p	PTM Enzyme	Source Select all PRO	PMID
	PR:000047698 (hHIPK2/PhosRes+)	p		PRO

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Tyrosine By position K32 Y44 S121 K228 K343 K355 Y558 S882 R1151 Y1197	Variant Select all D558 G121 G882 H44 N228 N32 N343 Q1151 S1197 T355	Source Select all Biomuta	Disease [Sample source] Select all DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] [ cosmic ]
K32	N32	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y44	H44	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S121	G121	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K228	N228	Biomuta	DOID:363 / uterine cancer [ icgc ]
K343	N343	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
K355	T355	Biomuta	DOID:3571 / liver cancer [ cosmic ]
Y558	D558	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
S882	G882	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
R1151	Q1151	Biomuta	DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y1197	S1197	Biomuta	[ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9H2X6 (HIPK2)

Protein Information

Interactive Sequence View

Q9H2X6 (HIPK2) as Substrate

Q9H2X6 (HIPK2) as PTM Enzyme

Proteoforms

PTM sites affected in variants