iPTMnet Report for Q9H2U1 (DHX36)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H2U1 / DHX36_HUMAN
Protein Name ATP-dependent DNA/RNA helicase DHX36
Gene Name Name: DHX36
Synonyms:DDX36;
Organism Homo sapiens (Human)

PRO ID PR:Q9H2U1
DAG View
PRO Name ATP-dependent DNA/RNA helicase DHX36 (human)
Definition An ATP-dependent DNA/RNA helicase DHX36 that is encoded in the genome of human.
Short Label hDHX36
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H2U1 (DHX36) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
Y3 Phosphorylation PhosphoSitePlus
R11 Methylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
Y22 Phosphorylation PhosphoSitePlus
R34 Methylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
R50 Methylation PhosphoSitePlus
R52 Methylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
R90 Methylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
T133 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
K139 Acetylation PhosphoSitePlus
K139 Ubiquitination PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S161 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
Y162 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S167 Phosphorylation phospho.ELM 18669648
Y169 Phosphorylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
Y248 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
T534 Phosphorylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
C611 Methylation IEDB 31844290
Y626 Phosphorylation PhosphoSitePlus
S656 Phosphorylation PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
K817 Ubiquitination PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K845 Acetylation PhosphoSitePlus
K853 Acetylation PhosphoSitePlus
K858 Ubiquitination PhosphoSitePlus
Y860 Phosphorylation PhosphoSitePlus
K862 Ubiquitination PhosphoSitePlus
K947 Acetylation PhosphoSitePlus   UniProt 19608861
K947 Ubiquitination PhosphoSitePlus
K951 Ubiquitination PhosphoSitePlus
K960 Ubiquitination PhosphoSitePlus
S963 Phosphorylation PhosphoSitePlus   UniProt 23186163
K973 Ubiquitination PhosphoSitePlus
T994 Phosphorylation PhosphoSitePlus
Y1006 Phosphorylation PhosphoSitePlus
Y1007 Phosphorylation PhosphoSitePlus
S1008 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S161 Phosphorylation HPRD 18669648
Y162 Phosphorylation HPRD 18669648
S167 Phosphorylation HPRD 18669648
S1008 Phosphorylation HPRD 18669648, 15144186


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R11 C11 Biomuta DOID:4159 / skin cancer [ cosmic ]
S36 F36 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S36 P36 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R47 Q47 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R50 S50 Biomuta DOID:10534 / stomach cancer [ cosmic ]
R52 W52 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
R90 Q90 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R90 * Biomuta DOID:1319 / brain cancer [ cosmic ]
T133 A133 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K145 N145 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K153 N153 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S161 L161 Biomuta DOID:4159 / skin cancer [ cosmic ]
K183 N183 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K190 N190 Biomuta DOID:1324 / lung cancer [ cosmic ]
K214 M214 Biomuta DOID:4159 / skin cancer [ cosmic ]
K432 I432 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
C611 S611 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K829 M829 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K845 N845 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K853 R853 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K947 N947 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S963 N963 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
Y1007 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S1008 C1008 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1008 N1008 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]