iPTMnet Report for Q9H2S1 (KCNN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H2S1 / KCNN2_HUMAN
Protein Name Small conductance calcium-activated potassium channel protein 2
Gene Name Name: KCNN2
Organism Homo sapiens (Human)

PRO ID PR:Q9H2S1
DAG View
PRO Name small conductance calcium-activated potassium channel protein 2 (human)
Definition A small conductance calcium-activated potassium channel protein 2 that is encoded in the genome of human.
Short Label hKCNN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H2S1 (KCNN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y6 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
T90 Phosphorylation HPRD   PhosphoSitePlus 18452278
Y119 Phosphorylation PhosphoSitePlus
S135 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 16513649
K293 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
S464 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   Signor 16513649
K466 Sumoylation PhosphoSitePlus
K484 Acetylation PhosphoSitePlus
T516 Phosphorylation PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
R566 Methylation PhosphoSitePlus
S567 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   Signor 16513649
S568 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   Signor 16513649
S569 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   Signor 16513649
T574 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S18 C18 Biomuta DOID:263 / kidney cancer [ cosmic ]
T90 A90 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S135 C135 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K293 N293 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
T516 I516 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S562 Y562 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S562 C562 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R566 L566 Biomuta DOID:1324 / lung cancer [ cosmic ]
R566 W566 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]