Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H2K2 / TNKS2_HUMAN
Protein Name Poly [ADP-ribose] polymerase tankyrase-2
Gene Name Name: TNKS2
Synonyms:PARP5B;
Organism Homo sapiens (Human)

PRO ID PR:Q9H2K2
DAG View
PRO Name poly [ADP-ribose] polymerase tankyrase-2 (human)
Definition A poly [ADP-ribose] polymerase tankyrase-2 that is encoded in the genome of human.
Short Label hTNKS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H2K2 (TNKS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T45 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K242 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K398 Ubiquitination PhosphoSitePlus
K410 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K592 Ubiquitination PhosphoSitePlus
K602 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus
K620 Ubiquitination PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
K654 Ubiquitination PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
S666 Phosphorylation PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
K928 Ubiquitination PhosphoSitePlus
K996 Ubiquitination PhosphoSitePlus
T1010 Phosphorylation PhosphoSitePlus
S1017 Phosphorylation HPRD   PhosphoSitePlus 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T45 M45 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K177 E177 Biomuta DOID:363 / uterine cancer [ tcga ]
K398 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K425 N425 Biomuta DOID:3571 / liver cancer [ icgc ]
T619 K619 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K633 Q633 Biomuta DOID:363 / uterine cancer [ tcga ]
K654 T654 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K996 N996 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T1010 S1010 Biomuta DOID:1324 / lung cancer [ tcga ]