iPTMnet Report for Q9H2K2 (TNKS2)
Protein Information
| UniProt AC / UniProt ID | Q9H2K2 / TNKS2_HUMAN |
| Protein Name | Poly [ADP-ribose] polymerase tankyrase-2 |
| Gene Name | Name: TNKS2 Synonyms:PARP5B; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9H2K2 |
| PRO Name | poly [ADP-ribose] polymerase tankyrase-2 (human) |
| Definition | A poly [ADP-ribose] polymerase tankyrase-2 that is encoded in the genome of human. |
| Short Label | hTNKS2 |
| Category | organism-gene |
DAG ViewQ9H2K2 (TNKS2) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T45 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K48 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K169 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K177 | Acetylation | score1 | PhosphoSitePlus | |||
| K177 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K178 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K211 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K225 | Ubiquitination | score1 | PhosphoSitePlus | |||
| H238 | Dihydroxylation | score2 | IntAct | 21251231 | ||
| K242 | Ubiquitination | score1 | PhosphoSitePlus | |||
| C293 | Methylation | score1 | IEDB | 31844290 | ||
| K323 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K331 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K359 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S374 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K378 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K380 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K398 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K410 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K421 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K425 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K501 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K510 | Ubiquitination | score1 | PhosphoSitePlus | |||
| H553 | Dihydroxylation | score2 | IntAct | 21251231 | ||
| K555 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K557 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K592 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K602 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K604 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K609 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T619 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K620 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K633 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K654 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K663 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S666 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K743 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K869 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K928 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K996 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T1010 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1017 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 19651622 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| T45 | M45 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K177 | E177 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K398 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| T619 | K619 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K633 | Q633 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K654 | T654 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| K996 | N996 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| T1010 | S1010 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
