Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9H1R3 / MYLK2_HUMAN
Protein Name Myosin light chain kinase 2, skeletal/cardiac muscle
Gene Name Name: MYLK2
Organism Homo sapiens (Human)

DAG View
PRO Name myosin light chain kinase 2, skeletal/cardiac muscle (human)
Definition A myosin light chain kinase 2, skeletal/cardiac muscle that is encoded in the genome of human.
Short Label hMYLK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9H1R3 (MYLK2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S143 Phosphorylation PhosphoSitePlus
S151 Phosphorylation neXtProt 11795875
S151 Phosphorylation P49137 (MAPKAPK2) neXtProt 11795875
K561 Ubiquitination PhosphoSitePlus
Y563 Phosphorylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
S588 Phosphorylation PhosphoSitePlus

Q9H1R3 (MYLK2) as PTM Enzyme

Substrate Site Score Source PMID
Q06413 (MEF2C) T80 PhosphoSitePlus   Signor 21556048

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q06413 (MEF2C) T80 Q9H1R3 (MYLK2) unknown eFIP 21556048

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S588 L588 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]