iPTMnet Report for Q9H1K1 (ISCU)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H1K1 / ISCU_HUMAN
Protein Name Iron-sulfur cluster assembly enzyme ISCU precursor
Gene Name Name: ISCU
Synonyms:NIFUN;
Organism Homo sapiens (Human)

PRO ID PR:Q9H1K1
DAG View
PRO Name iron-sulfur cluster assembly enzyme ISCU (human)
Definition An iron-sulfur cluster assembly enzyme ISCU that is encoded in the genome of human.
Short Label hISCU
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H1K1 (ISCU) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R11 Methylation IEDB 27503676
S14 Phosphorylation P42345 (MTOR) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 23508953
S20 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus   RLIMS-P 21725060
Y43 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
K57 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
S97 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S101 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S102 Phosphorylation phospho.ELM 18669648
K112 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S14 Phosphorylation HPRD 19664994
S29 Phosphorylation HPRD 20068231
S97 Phosphorylation HPRD 18669648
S101 Phosphorylation HPRD 18669648
S102 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
T12 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y18 Phosphorylation HPRD   PhosphoSitePlus 20068231
S26 Phosphorylation PhosphoSitePlus
S72 Phosphorylation HPRD 18669648
S76 Phosphorylation HPRD 18669648
S77 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S26 Y26 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S29 L29 Biomuta DOID:4159 / skin cancer [ cosmic ]
K57 E57 Biomuta DOID:10283 / prostate cancer [ icgc ]
K112 N112 Biomuta DOID:1324 / lung cancer [ cosmic ]
K147 R147 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]