iPTMnet Report for Q9H1B5 (XYLT2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H1B5 / XYLT2_HUMAN
Protein Name Xylosyltransferase 2
Gene Name Name: XYLT2
Synonyms:XT2;ORFNames:UNQ3058/PRO9878;
Organism Homo sapiens (Human)

PRO ID PR:Q9H1B5
DAG View
PRO Name xylosyltransferase 2 (human)
Definition A xylosyltransferase 2 that is encoded in the genome of human.
Short Label hXYLT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H1B5 (XYLT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S61 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T64 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S67 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
R76 Methylation PhosphoSitePlus
S87 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
T100 Phosphorylation PhosphoSitePlus
S146 O-Glycosylation GlyGen 25813380
T154 O-Glycosylation GlyGen 30459171, 25813380
T159 O-Glycosylation GlyGen 25813380
Y256 Phosphorylation PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K468 Ubiquitination PhosphoSitePlus
Y536 Phosphorylation PhosphoSitePlus
T571 O-Glycosylation GlyGen   PhosphoSitePlus 23584533, 25813380
S777 O-Glycosylation GlyGen 30459171
S782 O-Glycosylation GlyGen 30459171
S783 O-Glycosylation GlyGen 30459171


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P01116 (KRAS) Y64 Q9H1B5 (XYLT2) unknown eFIP 33680360


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S67 L67 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T154 M154 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K355 * Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K355 R355 Biomuta DOID:4159 / skin cancer [ cosmic ]