iPTMnet Report for Q9H0J9 (PARP12)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0J9 / PAR12_HUMAN
Protein Name Protein mono-ADP-ribosyltransferase PARP12
Gene Name Name: PARP12
Synonyms:ZC3HDC1;
Organism Homo sapiens (Human)

PRO ID PR:Q9H0J9
DAG View
PRO Name protein mono-ADP-ribosyltransferase PARP12 (human)
Definition A protein mono-ADP-ribosyltransferase PARP12 that is encoded in the genome of human.
Short Label hPARP12
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0J9 (PARP12) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S70 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y183 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S258 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
S259 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S263 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231
T266 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S285 Phosphorylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K326 Ubiquitination PhosphoSitePlus
S360 Phosphorylation HPRD 20068231
K410 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K454 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K482 Ubiquitination PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
K500 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K528 Ubiquitination PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S70 L70 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
K196 R196 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S259 L259 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S263 P263 Biomuta DOID:363 / uterine cancer [ icgc ]
T266 I266 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
K428 R428 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K482 N482 Biomuta DOID:1324 / lung cancer [ cosmic ]
S483 R483 Biomuta DOID:3571 / liver cancer [ cosmic ]