Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0H5 / RGAP1_HUMAN
Protein Name Rac GTPase-activating protein 1
Gene Name Name: RACGAP1
Synonyms:KIAA1478;
Organism Homo sapiens (Human)

PRO ID PR:Q9H0H5
DAG View
PRO Name Rac GTPase-activating protein 1 (human)
Definition A Rac GTPase-activating protein 1 that is encoded in the genome of human.
Short Label hRACGAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0H5 (RACGAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K53 Ubiquitination PhosphoSitePlus
K60 Sumoylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S144 Phosphorylation Q96GD4 (AURKB) HPRD   phospho.ELM   PhosphoSitePlus   Signor 18669648, 14744859, 19007248
T145 Phosphorylation Q96GD4 (AURKB) HPRD   PhosphoSitePlus   Signor 14744859, 19007248
S149 Phosphorylation P53350 (PLK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19468302, 18669648, 19468300, ...28884018
S151 Phosphorylation PhosphoSitePlus
S154 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 19007248, 18452278, ...18669648, 19690332, 20068231
S157 Phosphorylation P53350 (PLK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19468302, 21406692, 19468300, ...18669648, 19007248, 25068414, 28884018, 18452278, 19690332, 20068231
T161 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 16565220
S164 Phosphorylation P53350 (PLK1) HPRD   IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19468302, 19468300, 17081983, ...25068414, 16565220, 18669648, 28884018, 25486482
S169 Phosphorylation HPRD   PhosphoSitePlus 19691289
S170 Phosphorylation P53350 (PLK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19468302, 19468300, 19691289, ...16565220, 19007248, 28884018
K173 Ubiquitination PhosphoSitePlus
S185 Phosphorylation Q96GD4 (AURKB) HPRD   phospho.ELM   PhosphoSitePlus   Signor 14744859, 17287340
T186 Phosphorylation Q96GD4 (AURKB) HPRD   PhosphoSitePlus   Signor 14744859
S187 Phosphorylation Q96GD4 (AURKB) HPRD   phospho.ELM   PhosphoSitePlus   Signor 14744859, 17287340
K199 Sumoylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
T201 Phosphorylation HPRD 20068231
S203 Phosphorylation O14757 (CHEK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 23186163, 18212344, ...16964243, 19007248, 18452278, 19651622, 22067460, 18669648, 21851590, 16565220, 19690332, 20068231, 19691289
S206 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 19007248, ...19651622, 18669648, 19690332, 18212344
S214 Phosphorylation P53350 (PLK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19468302, 19468300, 23186163, ...19691289, 19007248, 16565220, 20068231
S234 Phosphorylation HPRD 20068231
Y241 Phosphorylation HPRD   PhosphoSitePlus 20068231
T243 Phosphorylation HPRD 20068231
K248 Sumoylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
T249 Phosphorylation Q96GD4 (AURKB) , P31751 (AKT2) PhosphoSitePlus   RLIMS-P   UniProt 22267324, 24019536, 23186163
T251 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S257 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 18669648, 23186163, ...22067460
S259 Phosphorylation PhosphoSitePlus
T260 Phosphorylation P53350 (PLK1) neXtProt   PhosphoSitePlus   Signor   UniProt 19468302, 19468300
S274 Phosphorylation PhosphoSitePlus
T277 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 19691289, 20068231
S280 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K296 Sumoylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S299 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K311 Sumoylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
T342 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 20068231, ...16565220
S359 Phosphorylation PhosphoSitePlus
S387 Phosphorylation Q96GD4 (AURKB) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22945935, 12689593
K404 Ubiquitination PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
S410 Phosphorylation Q96GD4 (AURKB) HPRD   phospho.ELM   UniProt 15108802, 12689593
K411 Ubiquitination PhosphoSitePlus
S420 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
S533 Phosphorylation HPRD 20068231
S540 Phosphorylation HPRD 20068231
S563 Phosphorylation HPRD   PhosphoSitePlus 20068231
T564 Phosphorylation HPRD   PhosphoSitePlus 20068231
T567 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K571 Sumoylation PhosphoSitePlus
S573 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T579 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 18669648, 20068231
T580 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 23186163, 16964243, ...16565220, 22067460, 18669648, 20068231
K587 Methylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
T588 Phosphorylation P06493 (CDK1) HPRD   IntAct   phospho.ELM   PhosphoSitePlus   UniProt 16964243, 16565220, 22067460, ...18669648, 18201571, 20068231
S590 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 22067460, 18669648, 20068231, ...16565220
S591 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19691289, 19007248, 22067460, ...18669648, 20068231, 20068230
S592 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 19007248
S593 Phosphorylation HPRD   PhosphoSitePlus 19007248, 19691289
S595 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S600 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 20068231
T601 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 20068231
T603 Phosphorylation HPRD   PhosphoSitePlus 20068231
K604 Ubiquitination PhosphoSitePlus
T606 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 20068231, ...17924679
S611 Phosphorylation PhosphoSitePlus
K614 Methylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
S628 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16565220, 22067460, ...18669648, 20068231, 17924679
K632 Acetylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9H0H5 (RACGAP1) T588 P06493 (CDK1) unknown eFIP 18201571
Phosphorylation Q9H0H5 (RACGAP1) S164 Q9H8V3 (ECT2) unknown eFIP 25068414
Phosphorylation Q9H0H5 (RACGAP1) T249 P46940 (IQGAP1) increased_association eFIP 24019536


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S151 Y151 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S185 T185 Biomuta DOID:1324 / lung cancer [ tcga ]
T260 N260 Biomuta DOID:3571 / liver cancer [ icgc ]
S299 F299 Biomuta DOID:1909 / melanoma [ tcga ]
K311 R311 Biomuta DOID:363 / uterine cancer [ tcga ]
S387 C387 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S410 C410 Biomuta DOID:3571 / liver cancer [ tcga ]
K411 N411 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S420 R420 Biomuta DOID:3571 / liver cancer [ icgc ]
S563 L563 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T579 I579 Biomuta DOID:1324 / lung cancer [ cosmic ]
S628 P628 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]