iPTMnet Report for Q9H0H3 (KLHL25)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0H3 / KLH25_HUMAN
Protein Name Kelch-like protein 25
Gene Name Name: KLHL25
Synonyms:ENC2;
Organism Homo sapiens (Human)

PRO ID PR:Q9H0H3
DAG View
PRO Name kelch-like protein 25 (human)
Definition A kelch-like protein 25 that is encoded in the genome of human.
Short Label hKLHL25
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0H3 (KLHL25) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S13 Phosphorylation HPRD   phospho.ELM 18669648
S14 Phosphorylation HPRD   phospho.ELM 18669648
Y70 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
T284 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
C307 Methylation IEDB 31844290
Y311 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
Y343 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
R551 Methylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y70 C70 Biomuta DOID:184 / bone cancer [ cosmic ]
K263 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K316 R316 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K323 R323 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S406 L406 Biomuta DOID:10534 / stomach cancer [ cosmic ]