iPTMnet Report for Q9H0E9 (BRD8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0E9 / BRD8_HUMAN
Protein Name Bromodomain-containing protein 8
Gene Name Name: BRD8
Synonyms:SMAP,SMAP2;
Organism Homo sapiens (Human)

PRO ID PR:Q9H0E9
DAG View
PRO Name bromodomain-containing protein 8 (human)
Definition A bromodomain-containing protein 8 that is encoded in the genome of human.
Short Label hBRD8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0E9 (BRD8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus
K7 Acetylation PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
T16 Phosphorylation PhosphoSitePlus
S20 Phosphorylation PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
K85 Acetylation PhosphoSitePlus
R124 Phosphorylation UniProt 18669648, 19690332, 24275569
L128 Phosphorylation UniProt 18669648, 19690332, 24275569
S136 Phosphorylation PhosphoSitePlus
D144 Phosphorylation UniProt 18669648
K148 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
T175 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
S262 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
A264 Phosphorylation UniProt 18669648, 19690332, 24275569
S268 Phosphorylation UniProt 18669648, 19690332, 24275569
T276 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
T279 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
T280 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
S284 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
S284 Phosphorylation UniProt 18669648
T286 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
T287 O-Glycosylation GlyGen 23301498, 26960196, 32938750, ...35138101, 30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
S290 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
S383 Phosphorylation PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus   UniProt 19367720, 23186163
T479 Phosphorylation PhosphoSitePlus
K481 Acetylation PhosphoSitePlus   UniProt 19608861
K481 Sumoylation PhosphoSitePlus
R502 Methylation PhosphoSitePlus
K509 Sumoylation PhosphoSitePlus
T569 Phosphorylation PhosphoSitePlus
K575 Sumoylation PhosphoSitePlus
T576 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus   UniProt 23186163
S582 Phosphorylation PhosphoSitePlus
S585 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S610 Phosphorylation PhosphoSitePlus
K612 Sumoylation PhosphoSitePlus
S615 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
S621 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S637 Phosphorylation PhosphoSitePlus   UniProt 17081983, 24275569
S641 Phosphorylation PhosphoSitePlus   UniProt 20068231, 17081983, 24275569
S656 Phosphorylation PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
L924 Phosphorylation UniProt 20068231
S1001 O-Glycosylation GlyGen 23301498, 26960196, 35138101, ...30379171, 29351928, 34725712, 31492838, 35254053, 35132862, 32119511, 30620550, 28657654
T1151 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1152 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation HPRD 20068231
T175 Phosphorylation HPRD 20068231
T569 Phosphorylation HPRD 19691289
S579 Phosphorylation HPRD 18452278
S621 Phosphorylation HPRD 20068231
S637 Phosphorylation HPRD 19651622, 17081983
S641 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 18452278
T1151 Phosphorylation HPRD 17081983, 20068231
S1152 Phosphorylation HPRD 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S136 Phosphorylation HPRD 20068231
T175 Phosphorylation HPRD   PhosphoSitePlus 20068231
K262 Acetylation PhosphoSitePlus
T264 Phosphorylation HPRD   PhosphoSitePlus 16964243, 20230923, 18452278, ...19651622, 18669648, 20068231, 17081983
S268 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16964243, 20230923, 19651622, ...18669648, 20068231, 17081983
S272 Phosphorylation PhosphoSitePlus
T283 Phosphorylation PhosphoSitePlus
S284 Phosphorylation HPRD   PhosphoSitePlus 17081983, 19664994, 19651622, ...18669648, 20068231
T642 Phosphorylation HPRD 19691289
S652 Phosphorylation HPRD 18452278
S694 Phosphorylation HPRD 20068231
S710 Phosphorylation HPRD 19651622, 17081983
S714 Phosphorylation HPRD 19413330, 19651622, 17081983, ...20068231, 18452278
S919 Phosphorylation HPRD 20068231
S924 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K9 N9 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
D144 N144 Biomuta DOID:1612 / breast cancer [ icgc ]
K149 N149 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K149 Q149 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S268 F268 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
S284 I284 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
T479 M479 Biomuta [ cosmic ]
K509 N509 Biomuta DOID:363 / uterine cancer [ icgc ]
S579 F579 Biomuta DOID:263 / kidney cancer [ cosmic ]
S608 P608 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S652 F652 Biomuta DOID:263 / kidney cancer [ cosmic ]
S851 P851 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S919 N919 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S924 P924 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1001 L1001 Biomuta DOID:1612 / breast cancer [ cosmic ]