iPTMnet Report for Q9H0E3 (SAP130)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0E3 / SP130_HUMAN
Protein Name Histone deacetylase complex subunit SAP130
Gene Name Name: SAP130
Organism Homo sapiens (Human)

PRO ID PR:Q9H0E3
DAG View
PRO Name histone deacetylase complex subunit SAP130 (human)
Definition A histone deacetylase complex subunit SAP130 that is encoded in the genome of human.
Short Label hSAP130
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0E3 (SAP130) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R5 Methylation PhosphoSitePlus
R34 Methylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
S108 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T122 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T129 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
R232 Methylation PhosphoSitePlus   UniProt 24129315
S300 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S300 Phosphorylation PhosphoSitePlus
T304 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T305 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T306 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S313 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T319 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S321 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S327 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S331 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
R344 Methylation PhosphoSitePlus
T346 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...32938750, 35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S349 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S349 Phosphorylation PhosphoSitePlus
T355 O-Glycosylation GlyGen 32574038
T355 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T439 Phosphorylation PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
S442 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
R444 Methylation PhosphoSitePlus
R453 Methylation PhosphoSitePlus
S454 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S454 Phosphorylation PhosphoSitePlus
S455 O-Glycosylation GlyGen 34846842
S455 Phosphorylation PhosphoSitePlus
S460 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S460 Phosphorylation PhosphoSitePlus
R463 Methylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus   UniProt 23186163
S480 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T491 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S495 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T503 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T505 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T508 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S509 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S510 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S512 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T513 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S635 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
S639 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T646 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T657 O-Glycosylation GlyGen 27655845, 34846842, 33214551, ...35254053, 30397120, 30379171, 32574038, 34725712, 34019948, 30059200, 35132862, 22661428, 31492838, 32119511, 35289036, 29351928, 28657654, 29237092
T677 Phosphorylation PhosphoSitePlus
T695 O-Glycosylation GlyGen 22661428
K783 Sumoylation PhosphoSitePlus
K785 Sumoylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
T853 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
T856 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
K869 Methylation PhosphoSitePlus
K869 Sumoylation PhosphoSitePlus
S875 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y880 Phosphorylation PhosphoSitePlus
K937 Ubiquitination PhosphoSitePlus
K979 Ubiquitination PhosphoSitePlus
K981 Ubiquitination PhosphoSitePlus
K1023 Ubiquitination PhosphoSitePlus
K1028 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S349 Phosphorylation HPRD 20068231
T355 Phosphorylation HPRD 18669648, 20068231
T439 Phosphorylation HPRD 20068231
S442 Phosphorylation HPRD 18669648, 19691289, 20068231
S465 Phosphorylation HPRD 19691289, 20068231
S798 Phosphorylation HPRD 20068231
T805 Phosphorylation HPRD 20068231
S811 Phosphorylation HPRD 20068231
S831 Phosphorylation HPRD 20068231
T853 Phosphorylation HPRD 17081983
S855 Phosphorylation HPRD 17081983, 20068231, 18452278
T856 Phosphorylation HPRD 20068231, 18452278
S875 Phosphorylation HPRD 18669648, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S226 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S696 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S72 F72 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S72 Y72 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S108 L108 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R232 Q232 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R232 L232 Biomuta DOID:4159 / skin cancer [ cosmic ]
T305 M305 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ icgc ]
S349 C349 Biomuta DOID:1324 / lung cancer [ cosmic ]
T355 M355 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R444 Q444 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R444 W444 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S460 F460 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S510 F510 Biomuta DOID:4159 / skin cancer [ cosmic ]
S639 G639 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S709 P709 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S798 F798 Biomuta DOID:4159 / skin cancer [ cosmic ]
T805 A805 Biomuta DOID:1324 / lung cancer [ cosmic ]
S831 Y831 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K869 R869 Biomuta DOID:263 / kidney cancer [ cosmic ]
K869 N869 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]