Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9H0C8 / ILKAP_HUMAN
Protein Name Integrin-linked kinase-associated serine/threonine phosphatase 2C
Gene Name Name: ILKAP
Organism Homo sapiens (Human)

DAG View
PRO Name integrin-linked kinase-associated serine/threonine phosphatase 2C (human)
Definition An integrin-linked kinase-associated serine/threonine phosphatase 2C that is encoded in the genome of human.
Short Label hILKAP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9H0C8 (ILKAP) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 21406692, 22814378, 22223895, ...20068231
S13 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...19651622, 20068231
T81 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus
K86 Acetylation PhosphoSitePlus
K95 Acetylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
C190 S-Nitrosylation dbSNO 19483679
K196 Ubiquitination PhosphoSitePlus
K204 Methylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K210 Acetylation PhosphoSitePlus   UniProt 19608861
K210 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
Y298 Phosphorylation PhosphoSitePlus
K299 Acetylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
R319 Methylation PhosphoSitePlus
R369 Methylation PhosphoSitePlus
R377 Methylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S82 F82 Biomuta DOID:363 / uterine cancer [ tcga ]
S82 Y82 Biomuta DOID:1909 / melanoma [ tcga ]
C190 S190 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K250 E250 Biomuta DOID:363 / uterine cancer [ tcga ]
K258 N258 Biomuta DOID:363 / uterine cancer [ tcga ]
Y265 * Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
S305 F305 Biomuta DOID:1909 / melanoma [ icgc ]
R377 W377 Biomuta DOID:363 / uterine cancer [ tcga ]