iPTMnet Report for Q9H0B6 (KLC2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H0B6 / KLC2_HUMAN
Protein Name Kinesin light chain 2
Gene Name Name: KLC2
Organism Homo sapiens (Human)

PRO ID PR:Q9H0B6
DAG View
PRO Name kinesin light chain 2 (human)
Definition A kinesin light chain 2 that is encoded in the genome of human.
Short Label hKLC2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H0B6 (KLC2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K11 Ubiquitination PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y192 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
Y292 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
K318 Ubiquitination PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
Y346 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
K378 Acetylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
K390 Ubiquitination PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
Y431 Phosphorylation PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
S436 Phosphorylation PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
K439 Methylation PhosphoSitePlus
S445 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 28228285, 18220336, ...18669648, 20068231, 16964243
T447 Phosphorylation IEDB   PhosphoSitePlus 28228285
Y459 Phosphorylation PhosphoSitePlus
K464 Acetylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
S507 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S508 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S519 Phosphorylation PhosphoSitePlus
S521 Phosphorylation PhosphoSitePlus   UniProt 23186163
S539 Phosphorylation Q13131 (PRKAA1) neXtProt   PhosphoSitePlus 21436401
S543 Phosphorylation PhosphoSitePlus
S545 Phosphorylation Q13131 (PRKAA1) PhosphoSitePlus 21725060
S556 Phosphorylation PhosphoSitePlus
S557 Phosphorylation PhosphoSitePlus
T568 Phosphorylation PhosphoSitePlus
S581 Phosphorylation Q13131 (PRKAA1) neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...21436401
S582 Phosphorylation Q13131 (PRKAA1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 21725060, 20068231
S589 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S602 Phosphorylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
S608 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   UniProt 20534517, 23186163
S609 Phosphorylation PhosphoSitePlus
S610 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648
S611 Phosphorylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus   UniProt 23186163
S618 Phosphorylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S13 Phosphorylation HPRD 20068231
S151 Phosphorylation HPRD 19651622, 20068231
S445 Phosphorylation HPRD 17322306, 19413330, 18669648, ...16964243, 20068231
S507 Phosphorylation HPRD 17081983
S508 Phosphorylation HPRD 17081983
S556 Phosphorylation HPRD 20068231
S581 Phosphorylation HPRD 17322306, 18212344, 18767875, ...19651622, 18669648, 20068231
S582 Phosphorylation HPRD 19413330, 18212344, 18767875, ...15302935, 19664995, 19651622, 19664994, 18669648, 20068231
S589 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S609 Phosphorylation HPRD 20058876
S610 Phosphorylation HPRD 18767875, 20058876, 19664995, ...17322306, 18669648, 19415658, 20068231
S611 Phosphorylation HPRD 18767875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S151 P151 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S374 F374 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y438 H438 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S445 G445 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S445 I445 Biomuta DOID:1324 / lung cancer [ cosmic ]
T447 A447 Biomuta DOID:363 / uterine cancer [ icgc ]
S539 F539 Biomuta DOID:4159 / skin cancer [ cosmic ]
S556 N556 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S556 C556 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T568 N568 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]