iPTMnet Report for Q9H040 (SPRTN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H040 / SPRTN_HUMAN
Protein Name DNA-dependent metalloprotease SPRTN
Gene Name Name: SPRTN
Synonyms:C1orf124,DVC1;ORFNames:UNQ1880/PRO4323;
Organism Homo sapiens (Human)

PRO ID PR:Q9H040
DAG View
PRO Name DNA-dependent metalloprotease SPRTN (human)
Definition A DNA-dependent metalloprotease SPRTN that is encoded in the genome of human.
Short Label hSPRTN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H040 (SPRTN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
T73 Phosphorylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
T154 Phosphorylation PhosphoSitePlus
K184 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K213 Sumoylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K230 Acetylation PhosphoSitePlus   UniProt 32649882
K230 Sumoylation PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
K241 Sumoylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus   UniProt 23186163
K271 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K303 Sumoylation PhosphoSitePlus
K341 Sumoylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus   UniProt 27871365
T355 Phosphorylation PhosphoSitePlus
K361 Sumoylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
S363 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31316063
S374 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31316063
S375 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus   UniProt 27871365
S382 Phosphorylation PhosphoSitePlus
S383 Phosphorylation RLIMS-P   UniProt 31316063
K384 Ubiquitination PhosphoSitePlus
T386 Phosphorylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K414 Ubiquitination PhosphoSitePlus   UniProt 27871365
K423 Sumoylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
K428 Sumoylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
K435 Sumoylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus   UniProt 27871365
S437 Phosphorylation PhosphoSitePlus
S444 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K484 Sumoylation PhosphoSitePlus
K484 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S268 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S80 G80 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K213 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K230 Q230 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K303 T303 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S373 L373 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S382 Y382 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S383 P383 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T386 M386 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K414 E414 Biomuta DOID:4159 / skin cancer [ cosmic ]
K424 R424 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K424 N424 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S437 N437 Biomuta [ cosmic ]