iPTMnet Report for Q9H000 (MKRN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9H000 / MKRN2_HUMAN
Protein Name E3 ubiquitin-protein ligase makorin-2
Gene Name Name: MKRN2
Synonyms:RNF62;ORFNames:HSPC070;
Organism Homo sapiens (Human)

PRO ID PR:Q9H000
DAG View
PRO Name E3 ubiquitin-protein ligase makorin-2 (human)
Definition A makorin-2 that is encoded in the genome of human.
Short Label hMKRN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9H000 (MKRN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Ubiquitination PhosphoSitePlus
C37 Methylation IEDB 31844290
K42 Ubiquitination PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
R52 Methylation PhosphoSitePlus
R57 Methylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus   UniProt 24275569
K143 Ubiquitination PhosphoSitePlus
Y164 Phosphorylation PhosphoSitePlus
C185 Methylation IEDB 31844290
K214 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K310 Ubiquitination PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus
T369 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S139 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C185 F185 Biomuta DOID:1324 / lung cancer [ cosmic ]
K310 E310 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K311 N311 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K319 N319 Biomuta DOID:363 / uterine cancer [ icgc ]
K334 E334 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]