Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9GZZ9 / UBA5_HUMAN
Protein Name Ubiquitin-like modifier-activating enzyme 5
Gene Name Name: UBA5
Organism Homo sapiens (Human)

DAG View
PRO Name ubiquitin-like modifier-activating enzyme 5 (human)
Definition A ubiquitin-like modifier-activating enzyme 5 that is encoded in the genome of human.
Short Label hUBA5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9GZZ9 (UBA5) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
Y53 Phosphorylation PhosphoSitePlus
S66 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus   UniProt 20068231
Y372 Phosphorylation PhosphoSitePlus
T373 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
S381 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T383 Phosphorylation phospho.ELM 18669648
T386 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
S393 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S66 Phosphorylation HPRD 20068231
Y68 Phosphorylation HPRD 20068231
S358 Phosphorylation HPRD 20068231
S381 Phosphorylation HPRD 18669648
T383 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 20068231
Y12 Phosphorylation HPRD 20068231
S302 Phosphorylation HPRD 20068231
S325 Phosphorylation HPRD 18669648
T327 Phosphorylation HPRD 18669648

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y53 C53 Biomuta DOID:1612 / breast cancer [ cosmic ]
K173 E173 Biomuta DOID:363 / uterine cancer [ tcga ]
K376 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S390 C390 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]