iPTMnet Report for Q9GZY8 (MFF)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9GZY8 / MFF_HUMAN
Protein Name Mitochondrial fission factor
Gene Name Name: MFF
Synonyms:C2orf33;ORFNames:AD030,AD033,GL004;
Organism Homo sapiens (Human)

PRO ID PR:Q9GZY8
DAG View
PRO Name mitochondrial fission factor (human)
Definition A mitochondrial fission factor that is encoded in the genome of human.
Short Label hMFF
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9GZY8 (MFF) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 O-Glycosylation GlyGen 30379171, 31492838, 30059200
S21 Phosphorylation PhosphoSitePlus
Y35 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
T40 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
S93 Phosphorylation IEDB   PhosphoSitePlus 29317506
S95 O-Glycosylation GlyGen 30379171, 31492838, 30059200
T106 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus   UniProt 20068231
T121 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T137 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
T138 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
A146 Phosphorylation UniProt 20068231, 24275569
R149 Phosphorylation UniProt 18669648, 20068231
K151 Phosphorylation UniProt 18669648, 20068231
K151 Ubiquitination PhosphoSitePlus
S155 Phosphorylation Q13131 (PRKAA1) IEDB   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26816379, 21406692, 29725013, ...17081983, 27920218, 31112535, 20068231
S157 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...20068231
S172 Phosphorylation Q13131 (PRKAA1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26816379, 18669648, 31112535
S177 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
T200 O-Glycosylation GlyGen 30379171, 31492838, 30059200
T200 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S202 O-Glycosylation GlyGen 30379171, 31492838, 30059200
S202 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S222 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus   UniProt 20068231
S233 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S258 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T115 Phosphorylation HPRD 20068231
T137 Phosphorylation HPRD 18669648, 17081983, 20068231
T138 Phosphorylation HPRD 18669648, 17081983, 20068231
S155 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18212344
S157 Phosphorylation HPRD 19651622, 17081983, 20068231, ...18212344
T200 Phosphorylation HPRD 20068231
S202 Phosphorylation HPRD 20068231
S229 Phosphorylation HPRD 20068231
S233 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
T80 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
T149 Phosphorylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S146 Phosphorylation PhosphoSitePlus
Y148 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T80 Phosphorylation PhosphoSitePlus
T89 Phosphorylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O00429 (DNM1L) S637 Q9GZY8 (MFF) unknown eFIP 26432782


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 C7 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S7 I7 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T40 S40 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T121 M121 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S146 Y146 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic, icgc, cosmic, icgc ]
R149 K149 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
R149 T149 Biomuta DOID:1612 / breast cancer [ cosmic ]
S172 Y172 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S223 F223 Biomuta DOID:4159 / skin cancer [ cosmic ]
S229 L229 Biomuta DOID:4159 / skin cancer [ cosmic ]