iPTMnet Report for Q9GZS1 (POLR1E)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9GZS1 / RPA49_HUMAN
Protein Name DNA-directed RNA polymerase I subunit RPA49
Gene Name Name: POLR1E
Synonyms:PAF53;
Organism Homo sapiens (Human)

PRO ID PR:Q9GZS1
DAG View
PRO Name DNA-directed RNA polymerase I subunit RPA49 (human)
Definition A DNA-directed RNA polymerase I subunit RPA49 that is encoded in the genome of human.
Short Label hPOLR1E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9GZS1 (POLR1E) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
R40 Methylation PhosphoSitePlus
K47 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
T64 Phosphorylation PhosphoSitePlus
R66 Methylation PhosphoSitePlus
K80 Methylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
Y131 Phosphorylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus   UniProt 21406692
K170 Ubiquitination PhosphoSitePlus
K179 Sumoylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
C253 Methylation IEDB 31844290
S265 Phosphorylation PhosphoSitePlus
K295 Methylation PhosphoSitePlus
S296 Phosphorylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K373 Acetylation PhosphoSitePlus   UniProt 24207024
S385 Phosphorylation PhosphoSitePlus
S390 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 20068231
S35 Phosphorylation HPRD 20068231
S163 Phosphorylation HPRD 18669648
S385 Phosphorylation HPRD 20068231
S390 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K373 E373 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]