iPTMnet Report for Q9GZR1 (SENP6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9GZR1 / SENP6_HUMAN
Protein Name Sentrin-specific protease 6
Gene Name Name: SENP6
Synonyms:KIAA0797,SSP1,SUSP1;ORFNames:FKSG6;
Organism Homo sapiens (Human)

PRO ID PR:Q9GZR1
DAG View
PRO Name sentrin-specific protease 6 (human)
Definition A sentrin-specific protease 6 that is encoded in the genome of human.
Short Label hSENP6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9GZR1 (SENP6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S9 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
S35 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus   UniProt 21406692
S55 Phosphorylation PhosphoSitePlus
K99 Methylation PhosphoSitePlus
T100 Phosphorylation PhosphoSitePlus
K102 Methylation PhosphoSitePlus
K189 Sumoylation PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K274 Sumoylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
T323 Phosphorylation PhosphoSitePlus
S335 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S336 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T345 Phosphorylation PhosphoSitePlus
S350 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S352 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S361 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S362 Phosphorylation PhosphoSitePlus
T398 Phosphorylation PhosphoSitePlus
K406 Sumoylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
T416 Phosphorylation PhosphoSitePlus   UniProt 23186163
K419 Sumoylation PhosphoSitePlus
K534 Ubiquitination PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
Y599 Phosphorylation PhosphoSitePlus
S606 Phosphorylation PhosphoSitePlus
T728 O-Glycosylation GlyGen 23301498, 30620550
K736 Ubiquitination PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus
K910 Ubiquitination PhosphoSitePlus
S916 Phosphorylation PhosphoSitePlus
S919 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
S985 Phosphorylation PhosphoSitePlus
K1086 Ubiquitination PhosphoSitePlus
S1111 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S42 Phosphorylation HPRD 19651622
T323 Phosphorylation HPRD 17322306, 18452278
S324 Phosphorylation HPRD 17322306
S326 Phosphorylation HPRD 17322306, 18452278
S335 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S336 Phosphorylation HPRD 19651622, 18669648, 17081983, ...18452278
S350 Phosphorylation HPRD 18669648
S352 Phosphorylation HPRD 19413330, 18669648, 19664994
S361 Phosphorylation HPRD 18669648
S919 Phosphorylation HPRD 19651622, 15302935


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T100 N100 Biomuta DOID:363 / uterine cancer [ icgc ]
T323 P323 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T398 I398 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y599 C599 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S869 N869 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1111 * Biomuta DOID:4159 / skin cancer [ cosmic ]