iPTMnet Report for Q9D2Y4 (Mlkl)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9D2Y4 / MLKL_MOUSE
Protein Name Mixed lineage kinase domain-like protein
Gene Name Name: Mlkl
Organism Mus musculus (Mouse)

PRO ID PR:Q9D2Y4
DAG View
PRO Name mixed lineage kinase domain-like protein (mouse)
Definition A mixed lineage kinase domain-like protein that is encoded in the genome of mouse.
Short Label mMLKL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9D2Y4 (Mlkl) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K50 Ubiquitination PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
N163 Ubiquitination PhosphoSitePlus
R208 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 24095729, 28807105, 28892415, ...24012422
S345 Phosphorylation Q9QZL0 (Ripk3) PhosphoSitePlus 24012422
S347 Phosphorylation PhosphoSitePlus   UniProt 24095729, 24012422
S347 Phosphorylation Q9QZL0 (Ripk3) PhosphoSitePlus 24012422
T349 O-Glycosylation GlyGen 30059200
T349 Phosphorylation PhosphoSitePlus   UniProt 24095729, 24012422
T349 Phosphorylation Q9QZL0 (Ripk3) PhosphoSitePlus 24012422
S352 Phosphorylation UniProt 24095729
S360 Phosphorylation PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
S441 Phosphorylation PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9QZL0 (Ripk3) T231 Q9D2Y4 (Mlkl) unknown eFIP 23612963