iPTMnet Report for Q9C0H6 (KLHL4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C0H6 / KLHL4_HUMAN
Protein Name Kelch-like protein 4
Gene Name Name: KLHL4
Synonyms:KIAA1687;
Organism Homo sapiens (Human)

PRO ID PR:Q9C0H6
DAG View
PRO Name kelch-like protein 4 (human)
Definition A kelch-like protein 4 that is encoded in the genome of human.
Short Label hKLHL4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C0H6 (KLHL4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K171 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
Y552 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S557 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K585 Ubiquitination PhosphoSitePlus
Y589 Phosphorylation PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y552 Phosphorylation HPRD 18669648
S557 Phosphorylation HPRD 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y552 Phosphorylation HPRD 18669648
S557 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S369 Y369 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S557 L557 Biomuta DOID:1319 / brain cancer [ cosmic ]
Y589 H589 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ]
Y589 * Biomuta DOID:10534 / stomach cancer [ cosmic ]