Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C0C7 / AMRA1_HUMAN
Protein Name Activating molecule in BECN1-regulated autophagy protein 1
Gene Name Name: AMBRA1
Synonyms:DCAF3;
Organism Homo sapiens (Human)

PRO ID PR:Q9C0C7
DAG View
PRO Name activating molecule in BECN1-regulated autophagy protein 1 (human)
Definition An activating molecule in BECN1-regulated autophagy protein 1 that is encoded in the genome of human.
Short Label hAMBRA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C0C7 (AMBRA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
K2 Ubiquitination PhosphoSitePlus
K7 Ubiquitination PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus   UniProt 23524951
S52 Phosphorylation P42345 (MTOR) PhosphoSitePlus 23524951
K175 Ubiquitination PhosphoSitePlus
R226 Methylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus   UniProt 23186163
S387 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
R392 Methylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus   UniProt 23186163
T440 O-Glycosylation GlyGen 29351928, 30059200, 28657654
S441 O-Glycosylation GlyGen 29351928, 30059200, 28657654
S443 Phosphorylation PhosphoSitePlus   UniProt 23186163
S465 Phosphorylation PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
S629 Phosphorylation PhosphoSitePlus
S635 Phosphorylation PhosphoSitePlus   UniProt 23186163
S639 Phosphorylation PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S696 Phosphorylation PhosphoSitePlus
S722 Phosphorylation PhosphoSitePlus
R730 Methylation PhosphoSitePlus
R747 Methylation PhosphoSitePlus
R754 Methylation PhosphoSitePlus
R795 Methylation PhosphoSitePlus
S797 Phosphorylation PhosphoSitePlus
S800 Phosphorylation PhosphoSitePlus
R808 Methylation PhosphoSitePlus
Y814 Phosphorylation PhosphoSitePlus
R824 Methylation PhosphoSitePlus
Y1026 Phosphorylation PhosphoSitePlus
T1028 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus   UniProt 30217973
T1127 O-Glycosylation GlyGen 29351928, 30059200, 28657654
S1191 Phosphorylation PhosphoSitePlus
S1192 Phosphorylation PhosphoSitePlus
T1203 Phosphorylation PhosphoSitePlus
S1204 Phosphorylation PhosphoSitePlus
S1205 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1227 Phosphorylation PhosphoSitePlus
T1238 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S549 Phosphorylation HPRD 18691976, 18669648, 19664995, ...20068231
T1113 Phosphorylation HPRD 18691976
S1114 Phosphorylation HPRD 19664995
S1115 Phosphorylation HPRD 18669648


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046329 (hAMBRA1/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K41 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R226 H226 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
R226 C226 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
R747 P747 Biomuta DOID:363 / uterine cancer [ tcga ]
R747 S747 Biomuta DOID:3571 / liver cancer [ icgc ]
R808 C808 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ]
S1043 F1043 Biomuta DOID:363 / uterine cancer [ tcga ]
T1203 N1203 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S1204 F1204 Biomuta DOID:1909 / melanoma [ icgc, tcga ]