iPTMnet Report for Q9C0C4 (SEMA4C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C0C4 / SEM4C_HUMAN
Protein Name Semaphorin-4C precursor
Gene Name Name: SEMA4C
Synonyms:KIAA1739,SEMAI;ORFNames:UNQ5855/PRO34487;
Organism Homo sapiens (Human)

PRO ID PR:Q9C0C4
DAG View
PRO Name semaphorin-4C (human)
Definition A semaphorin-4C that is encoded in the genome of human.
Short Label hSEMA4C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C0C4 (SEMA4C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N105 N-Glycosylation GlyGen 24190977
N106 N-Glycosylation GlyGen 23090970, 24190977
C137 Methylation IEDB 31844290
Y249 Phosphorylation PhosphoSitePlus
N419 N-Glycosylation GlyGen 23090970, 24190977
K481 Ubiquitination PhosphoSitePlus
S488 Phosphorylation PhosphoSitePlus
N522 N-Glycosylation GlyGen 23090970, 29741879, 24190977
C550 Methylation IEDB 31844290
T704 Phosphorylation PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
K713 Ubiquitination PhosphoSitePlus
S717 Phosphorylation PhosphoSitePlus
K729 Ubiquitination PhosphoSitePlus
Y736 Phosphorylation PhosphoSitePlus
Y737 Phosphorylation PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
S742 Phosphorylation PhosphoSitePlus   UniProt 23186163
K744 Ubiquitination PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
S772 Phosphorylation PhosphoSitePlus
Y789 Phosphorylation PhosphoSitePlus
S832 Phosphorylation HPRD   PhosphoSitePlus 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N105 S105 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
C550 R550 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S717 G717 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S717 I717 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y737 C737 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S742 F742 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S832 L832 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]