iPTMnet Report for Q9C0B5 (ZDHHC5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C0B5 / ZDHC5_HUMAN
Protein Name Palmitoyltransferase ZDHHC5
Gene Name Name: ZDHHC5
Synonyms:KIAA1748,ZNF375;
Organism Homo sapiens (Human)

PRO ID PR:Q9C0B5
DAG View
PRO Name palmitoyltransferase ZDHHC5 (human)
Definition A palmitoyltransferase ZDHHC5 that is encoded in the genome of human.
Short Label hZDHHC5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C0B5 (ZDHHC5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K7 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
Y91 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 32958780
K92 Acetylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus   UniProt 23186163
S274 Phosphorylation PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
S296 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18220336
S299 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T303 Phosphorylation PhosphoSitePlus
S305 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
Y323 Phosphorylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
S345 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T348 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T350 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y352 Phosphorylation PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S370 Phosphorylation PhosphoSitePlus
S371 Phosphorylation PhosphoSitePlus
S372 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus
S380 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
T385 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
Y396 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus   UniProt 23186163
S401 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus   UniProt 23186163
S409 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T411 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K414 Methylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus   UniProt 23186163
S422 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S423 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18220336
S425 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S427 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
S429 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K431 Methylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S432 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 15144186, 18669648, ...19690332, 20068231
T436 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S453 Phosphorylation PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
Y456 Phosphorylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
Y470 Phosphorylation PhosphoSitePlus
S484 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
S499 Phosphorylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
T524 Phosphorylation PhosphoSitePlus
S529 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y533 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 26334723, 31780775
S537 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
S554 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S569 Phosphorylation PhosphoSitePlus
T574 Phosphorylation PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
T598 Phosphorylation PhosphoSitePlus
R615 Methylation PhosphoSitePlus
R617 Methylation PhosphoSitePlus   UniProt 24129315
S621 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...18220336, 18669648, 19690332, 20068231
T627 Phosphorylation PhosphoSitePlus
Y630 Phosphorylation PhosphoSitePlus
S634 Phosphorylation PhosphoSitePlus
S636 Phosphorylation PhosphoSitePlus
S638 Phosphorylation PhosphoSitePlus
S639 Phosphorylation PhosphoSitePlus
S647 Phosphorylation PhosphoSitePlus
T659 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K667 Ubiquitination PhosphoSitePlus
K672 Ubiquitination PhosphoSitePlus
S679 Phosphorylation PhosphoSitePlus
S682 Phosphorylation PhosphoSitePlus
S684 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S693 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S694 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...18220336
T696 Phosphorylation PhosphoSitePlus
S704 Phosphorylation PhosphoSitePlus
T709 Phosphorylation PhosphoSitePlus
Y711 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y91 Phosphorylation HPRD 18083107
S247 Phosphorylation HPRD 18691976
S296 Phosphorylation HPRD 18669648
S299 Phosphorylation HPRD 18669648, 18452278
S345 Phosphorylation HPRD 19413330, 18669648
T348 Phosphorylation HPRD 19413330, 18669648
T350 Phosphorylation HPRD 19413330, 18669648
S376 Phosphorylation HPRD 17081983
S380 Phosphorylation HPRD 17081983, 18767875, 18452278, ...19651622, 18669648, 20166139, 20068231
S391 Phosphorylation HPRD 17081983
S395 Phosphorylation HPRD 17081983
S409 Phosphorylation HPRD 18669648, 18452278
T411 Phosphorylation HPRD 18669648, 18452278
S415 Phosphorylation HPRD 19651622
S422 Phosphorylation HPRD 18669648, 20068231
S423 Phosphorylation HPRD 19651622, 18669648, 20068231
S425 Phosphorylation HPRD 18669648, 17081983, 20068231
S429 Phosphorylation HPRD 18669648
S432 Phosphorylation HPRD 19651622, 18669648, 20068231
T436 Phosphorylation HPRD 18669648
S529 Phosphorylation HPRD 17389395, 17081983, 20068231
Y533 Phosphorylation HPRD 17389395
S554 Phosphorylation HPRD 18669648, 17081983, 20068231
S569 Phosphorylation HPRD 17081983
S573 Phosphorylation HPRD 20068231
T574 Phosphorylation HPRD 17081983
S577 Phosphorylation HPRD 20068231
S621 Phosphorylation HPRD 18691976, 18669648, 19415658, ...20068231, 18767875
Y630 Phosphorylation HPRD 19901323
T659 Phosphorylation HPRD 18669648, 20068231
S679 Phosphorylation HPRD 20068231
S682 Phosphorylation HPRD 20068231
S684 Phosphorylation HPRD 19413330, 18669648, 20068231
S693 Phosphorylation HPRD 19413330, 18669648, 20068231
S694 Phosphorylation HPRD 19413330, 18669648, 20068231
T696 Phosphorylation HPRD 19413330


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K82 N82 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K92 N92 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S296 C296 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y352 H352 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K374 N374 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T385 I385 Biomuta DOID:1612 / breast cancer [ icgc ]
S386 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S409 C409 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S432 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S453 Y453 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y456 F456 Biomuta DOID:263 / kidney cancer [ cosmic ]
S458 I458 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S499 Y499 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S537 L537 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S554 L554 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S554 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S569 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S573 L573 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S573 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S577 L577 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S590 P590 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S634 L634 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S638 I638 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S639 R639 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S682 T682 Biomuta [ cosmic ]
S682 L682 Biomuta DOID:4159 / skin cancer [ cosmic ]
T696 M696 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
S714 L714 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]