iPTMnet Report for Q9C0B1 (FTO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C0B1 / FTO_HUMAN
Protein Name Alpha-ketoglutarate-dependent dioxygenase FTO
Gene Name Name: FTO
Synonyms:KIAA1752;
Organism Homo sapiens (Human)

PRO ID PR:Q9C0B1
DAG View
PRO Name alpha-ketoglutarate-dependent dioxygenase FTO (human)
Definition An alpha-ketoglutarate-dependent dioxygenase FTO that is encoded in the genome of human.
Short Label hFTO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C0B1 (FTO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T4 Phosphorylation PhosphoSitePlus   UniProt 23186163
T6 Phosphorylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
C104 Methylation IEDB 31844290
C104 S-Nitrosylation dbSNO 19483679
Y106 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
C136 Methylation IEDB 31844290
T150 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K216 Acetylation PhosphoSitePlus   UniProt 19608861
K216 Sumoylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S240 O-Glycosylation GlyGen 29351928, 35132862, 34725712, ...28510447
S246 O-Glycosylation GlyGen 29351928, 35132862, 34725712, ...28510447
S256 Phosphorylation PhosphoSitePlus   RLIMS-P 33925955
S260 Phosphorylation PhosphoSitePlus
C308 Methylation IEDB 31844290
C338 Methylation IEDB 31844290
S355 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y199 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S55 G55 Biomuta DOID:1324 / lung cancer [ cosmic ]
C104 F104 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y106 C106 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
C136 S136 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y185 H185 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K194 R194 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S240 L240 Biomuta DOID:4159 / skin cancer [ cosmic ]
S246 I246 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S256 R256 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S260 F260 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S260 C260 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C308 F308 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]