iPTMnet Report for Q9C0A6 (SETD5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C0A6 / SETD5_HUMAN
Protein Name Histone-lysine N-methyltransferase SETD5
Gene Name Name: SETD5
Synonyms:KIAA1757;
Organism Homo sapiens (Human)

PRO ID PR:Q9C0A6
DAG View
PRO Name histone-lysine N-methyltransferase SETD5 (human)
Definition A histone-lysine N-methyltransferase SETD5 that is encoded in the genome of human.
Short Label hSETD5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C0A6 (SETD5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S72 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T136 Phosphorylation PhosphoSitePlus
K174 Acetylation PhosphoSitePlus
K178 Acetylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
Y322 Phosphorylation PhosphoSitePlus
T474 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
S541 Phosphorylation PhosphoSitePlus
T560 Phosphorylation PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus
S745 Phosphorylation PhosphoSitePlus
R757 Methylation PhosphoSitePlus
S760 Phosphorylation PhosphoSitePlus
K822 Ubiquitination PhosphoSitePlus
S829 Phosphorylation PhosphoSitePlus   UniProt 20068231
K832 Ubiquitination PhosphoSitePlus
Y838 Phosphorylation PhosphoSitePlus
S852 Phosphorylation PhosphoSitePlus
T855 Phosphorylation PhosphoSitePlus
S865 Phosphorylation PhosphoSitePlus
T870 Phosphorylation PhosphoSitePlus
Y885 Phosphorylation PhosphoSitePlus
S890 Phosphorylation PhosphoSitePlus
T903 Phosphorylation PhosphoSitePlus
Y987 Phosphorylation PhosphoSitePlus
S988 Phosphorylation PhosphoSitePlus
S1003 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
S1038 Phosphorylation PhosphoSitePlus
S1041 Phosphorylation PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus
S1094 Phosphorylation PhosphoSitePlus
S1096 Phosphorylation PhosphoSitePlus
S1118 Phosphorylation PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
S1125 Phosphorylation PhosphoSitePlus
S1131 Phosphorylation PhosphoSitePlus
S1144 Phosphorylation PhosphoSitePlus
S1198 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1233 Phosphorylation PhosphoSitePlus
S1246 Phosphorylation PhosphoSitePlus
R1263 Methylation PhosphoSitePlus
S1269 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
Y1299 Phosphorylation PhosphoSitePlus
S1301 Phosphorylation PhosphoSitePlus
S1333 Phosphorylation PhosphoSitePlus
S1339 Phosphorylation PhosphoSitePlus
T1357 Phosphorylation PhosphoSitePlus
T1368 Phosphorylation PhosphoSitePlus
R1417 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S72 Phosphorylation HPRD 18669648
S829 Phosphorylation HPRD 20068231
S852 Phosphorylation HPRD 20068231
T855 Phosphorylation HPRD 20068231
S1094 Phosphorylation HPRD 20068231
S1096 Phosphorylation HPRD 20068231
S1103 Phosphorylation HPRD 20068231
S1104 Phosphorylation HPRD 20068231
S1106 Phosphorylation HPRD 20068231
S1108 Phosphorylation HPRD 20068231
S1118 Phosphorylation HPRD 20068231
S1119 Phosphorylation HPRD 20068231
S1124 Phosphorylation HPRD 19413330
S1125 Phosphorylation HPRD 19413330
S1198 Phosphorylation HPRD 19413330
Y1299 Phosphorylation HPRD 18452278
S1301 Phosphorylation HPRD 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S72 L72 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K178 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S191 C191 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S591 F591 Biomuta DOID:4159 / skin cancer [ cosmic ]
R757 C757 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S760 * Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S829 N829 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y838 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S852 F852 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T870 S870 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1038 C1038 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1043 L1043 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1106 F1106 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1108 F1108 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1124 C1124 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1125 F1125 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1198 F1198 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1233 N1233 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1233 I1233 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1299 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1301 R1301 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R1417 S1417 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
R1417 C1417 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]