Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C004 / SPY4_HUMAN
Protein Name Protein sprouty homolog 4
Gene Name Name: SPRY4
Organism Homo sapiens (Human)

PRO ID PR:Q9C004
DAG View
PRO Name protein sprouty homolog 4 (human)
Definition A protein sprouty homolog 4 that is encoded in the genome of human.
Short Label hSPRY4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C004 (SPRY4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
T12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
Y52 Phosphorylation phospho.ELM   PhosphoSitePlus 15584898
T77 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
S125 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
K276 Ubiquitination PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T77 M77 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S280 R280 Biomuta DOID:3571 / liver cancer [ icgc ]